Chromatographic isolation and structural elucidation of secondary metabolites from the soil-inhabiting fungus Aspergillus fumigatus 3T-EGY

• Autorzy: Abdel-Aziz M. S. , Ghareeb M. A. , Saad A. M. , Refahy L. A. , Hamed A. A.

Identyfikatory

DOI

10.1556/1326.2017.00329

• Języki publikacji: EN

Abstrakty

EN

Eight compounds were isolated and identified from the soil-inhabiting fungus Aspergillus fumigatus 3T-EGY, namely, stearic acid (1), α-linolenic acid (2), physcion (3), di-(2-ethylhexyl) phthalate (4), 2,4,5,17-tetramethoxy pradimicin lactone (5), 3,5-dihydroxy-7-O-α-rhamnopyranoyl-2H-chromen-2-one (6), juglanthraquinone A-5-O-d-rhodosamine-(4′→1″)-2-deoxy-d-glucose (4″→1″′)-cinerulose B (7), and micropeptin (8). Their structures were determined on the basis of one-dimensional (1D-) and two-dimensional nuclear magnetic resonance (2D-NMR) [1H-, 13C-NMR, 1H-1H COSY (COrrelated SpectroscopY), and 1H-13C HMBC (Heteronuclear Multiple Bond Correlation) spectroscopy]. Compound 7 showed moderate in vitro antimicrobial activity against three pathogenic strains with inhibition zones values were ranged from 9.0 to 10.66 mm compared to neomycin as a positive control with inhibition zones values were ranged from 14.0 to 19.0 mm.

Słowa kluczowe

EN

Aspergillus fumigatus 3T-EGY; phenolics; juglanthraquinone A triglycoside; VLC; in vitro antimicrobial activity

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2018
• Tom: Vol. 30, no. 4
• Strony: 243--249
• Opis fizyczny: Bibliogr. 36 poz., rys.

Twórcy

autor

Abdel-Aziz M. S.

• Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, El-Bohouth Street 33, Dokki-Giza 12622, Egypt

autor

Ghareeb M. A.

• Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar 12411, Imbaba, Giza, Egypt

autor

Saad A. M.

• Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar 12411, Imbaba, Giza, Egypt

autor

Refahy L. A.

• Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar 12411, Imbaba, Giza, Egypt

autor

Hamed A. A.

• Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, El-Bohouth Street 33, Dokki-Giza 12622, Egypt

Bibliografia

• [1] Verpoorte R. Drug Dev. Today 1998, 3, 232.
• [2] Berdy J. J. Antibiot. (Tokyo) 2005, 58, 1.
• [3] AbadM. J.; AnsuateguI. M.; BermejioP. Arkivoc. 2007, 2, 116.
• [4] Muhsin T. M.; Al-Duboon A. A.; Khalaf K. T. Jordan J. Biol. Sci. 2011, 4, 205.
• [5] Adrio J.; DemainL.; ArnoldL. Int. Microbiol. 2003, 6, 191.
• [6] Rodrigues K. F.; Costa G. L.; Carvalho M. P., Epifanio R. D. A. World J. Microbiol. Biotechnol. 2005, 21, 1617.
• [7] Arora D. S.; ChandraP.; BrazP. J. Microbiol. 2010, 41, 465.
• [8] Archer D. B. Curr. Opin. Biotechnol. 2000, 11, 478.
• [9] Abdel-Aziz M. S.; Hezma A. M. Polym.-Plast. Technol. Eng. 2013, 52, 1503.
• [10] Collins C. H.; Lyne P. M. Microbiological Methods, 5th edition; Butterworth & Co. Pub. Ltd.: London, UK & Toronto, Canada, 1985.
• [11] Abdel-Aziz M. S.; Abou-El-Sherbini K. S.; Hamzawy E. M. A.; Amr M. H. A.; El-Dafrawy S. Appl. Biochem. Biotechnol. 2015, 176, 2225.
• [12] Zhao G. Z.; Liu X. Z.; Wu W. P. Fungal Diver. 2007, 26, 313.
• [13] Raper K. B.; Fennell D. I. The genus Aspergillus; Williams and Williams: Baltimore, Washington, 1965.
• [14] Zhao J.; Kong F.; Li R.; Wang X.; Wan Z.; Wang D. J. Clin. Microbiol. 2001, 39, 2261.
• [15] Chen Y. C. J. D.; Eisner M. M.; Kattar S. L.; . K.; Bui U. J. Clin. Microbiol. 2001, 39, 4042.
• [16] White N. A.; Dehal P. K.; Duncan J. M.; Williams N. A.; Gartland J. S.; Palfreyman J. W.; Cooke D. E. L. Mycol. Res. 2001, 105, 447.
• [17] Shaaban M.; Nasr H.; Hassan A. Z.; Asker M. S. Rev. Latinoamer. Quím. 2013, 41, 50.
• [18] Rekha M. K. R.; Manzur A. P. P.; Sapna K.; Abraham M.; Preethi G. U.; Sarita G. B.; Elyas K. K. Curr. Res. Microbiol. Biotechnol. 2014, 2, 530.
• [19] Der Satyender K. Y. Pharm. Chem. 2013, 5, 59.
• [20] Zhao J. L.; Liu P.; Duan J. A.; Qian Y. F. China Tradit. Herb. Drugs 2013, 44, 1245.
• [21] Bian-Na S.; He-Ding S.; Hong-Xi W.; Li-Xiang Y.; Zhi-Qing C.; YaD. Trop. J. Pharm. Res 2014, 13, 2071.
• [22] Batchelor J. G.; Cushley R. J.; Prestegard J. H. J. Org. Chem. 1974, 39, 1698.
• [23] Van D. D. Phytochemical investigation of two Crassulaceae species: Rhodiola rosea L., the New “Herbal Stress Buster,” and Sedum dasyphyllum L. [dissertation]; University of Genève: Genève, 2009.
• [24] AnkeH.; IlhamK.; ZahnerH.; LaatschH. Arch. Microbiol. 1980, 126, 223–230.
• [25] Engstrom G. W.; McDorman D. J.; Maroney M. J. J. Agric. Food Chem. 1980, 28, 1139.
• [26] Manojlovic N. T.; Solujic S.; Kristic L. J. J. Serb. Chem. Soc. 2000, 65, 555.
• [27] Turner W. B. Fungal Metabolites; Academic Press: New York, 1971.
• [28] Agarwal S. K.; Singh S. S.; Verma S.; Kumar S. J. Ethnopharmacol. 2000, 72, 43.
• [29] Dirar A. I.; Mohamed M. A.; Ahmed W. J.; Mohammed M. S.; Khalid H. S.; Garelnabi E. A. E. J. Pharmacogn. Phytochem. 2014, 3, 38.
• [30] El-Sayed O. H.; Asker M. M. S.; Shash S. M.; Hamed S. R. Int. J. Chem. Tech. Res 2015, 8, 58.
• [31] Yunt Z. S. Chemical investigation of Streptomyces albus heterologous expression strains and the biosynthesis of the aromatic polyketide griseorhodin [dissertation]; University of Bonn: İstanbul, Türkei, 2012.
• [32] Wang M.; Zhoo J.; Hung R.; Li G.; Zeug X.; Li X. Nat. Prod. Res. 2016, 30, 1796.
• [33] Shimasaka A.; Hawakwa Y.; Nakagawa M.; Furihata K.; Seto H.; Otake N. J. Antibiot. 1987, 40, 116.
• [34] Belofsky G. N.; James B. G.; Donald T. W.; Patrick F. D. Tetrahedron Lett. 1998, 39, 5497.
• [35] Li X.; Zhang Q.; Zhang A.; Gao J. J. Agric. Food Chem. 2012, 60, 3424.
• [36] Zhang H.; Tang Y.; Ruan C.; Bai X. Rec. Nat. Prod. 2016, 10, 1.

Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).