Synthesis and antifungal activity of new salicylic acid derivatives

• Autorzy: Wodnicka A. , Huzar E. , Krawczyk M. , Kwiecień H.

Identyfikatory

DOI

10.1515/pjct-2017-0019

• Języki publikacji: EN

Abstrakty

EN

A simple one-step procedure for synthesis of 1-methoxy-1-oxoalkan-2-yl salicylates and 1-methoxy-1-oxoalkan-2-yl 2-[(1-methoxy-1-oxoalkan-2-yl)oxy]benzoates by reaction of salicylic acid with several methyl 2-bromoalkanoates was developed. The reactions were carried out in N,N-dimethylformamide (DMF) in the presence of anhydrous potassium carbonate. Conditions for regioselective synthesis of target compounds were established. The developed procedure could be easily applied in the industrial production process. The new salicylic acid derivatives were obtained with satisfactory yields and were characterized by MS and ¹H NMR spectra. The fungicidal activity of the prepared compounds was tested in vitro against seven species of plant pathogenic fungi. The best results were observed for 1-methoxy-1-oxoalkan-2-yl salicylates which showed moderate or good activity against Botrytis cinerea and Rhizoctonia solani.

Słowa kluczowe

EN

salicylic acid; salicylates; antifungal activity

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2017
• Tom: Vol. 19, nr 1
• Strony: 143--148
• Opis fizyczny: Bibliogr. 31 poz., rys., tab.

Twórcy

autor

Wodnicka A.

• West Pomeranian University of Technology, Szczecin, Faculty of Chemical Technology and Engineering, Institute of Organic Chemical Technology, al. Piastów 42, 71-065 Szczecin, Poland

autor

Huzar E.

• West Pomeranian University of Technology, Szczecin, Faculty of Chemical Technology and Engineering, Institute of Organic Chemical Technology, al. Piastów 42, 71-065 Szczecin, Poland

autor

Krawczyk M.

• Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warszawa, Poland

autor

Kwiecień H.

• West Pomeranian University of Technology, Szczecin, Faculty of Chemical Technology and Engineering, Institute of Organic Chemical Technology, al. Piastów 42, 71-065 Szczecin, Poland

Bibliografia

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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).