Hydrogel microspheres containing dextran-based nanoparticles as novel anticancer drug delivery system

• Autorzy: Kulikowska-Darłak Aleksandra , Stefanek Agata , Wasiak-Wojasińska Iga , Wiechecka-Ożdżyńska Paulina , Ciach Tomasz

Identyfikatory

DOI

10.24425/cpe.2022.142282

• Języki publikacji: EN

Abstrakty

EN

Developing an effective and safe cancer therapy could significantly reduce the number of deaths and improve the quality of life of treated patients. Nowadays medicine has developed a wide range of anticancer chemotherapeutics but at the same time there is a lack of effective drug delivery methods. Therefore, the development of the targeted drug delivery system which will selectively release drug into the cancer cells is a key challenge of modern medicine. The main aim of the presented research was to investigate the targeting effect of a drug delivery system based on the controlled release of dextran nanoparticles containing the anticancer drug – doxorubicin from the alginate microspheres coated with chitosan multilayers. During the research the physicochemical properties of the alginate microspheres and its stability in the physiological environment were investigated. Moreover, the kinetics of the nanoparticles with doxorubicin release from the alginate microspheres covered with chitosan multilayers was characterized, depending on the thickness of the chitosan layer. Further, the cytotoxicity study of the alginate microspheres covered with chitosan multilayer and containing nanoparticles was performed to determine the therapeutic effect of the released nanoparticles with doxorubicin on the HeLa cells during the in vitro cell culture.

Słowa kluczowe

EN

alginate; dextran; nanoparticles; microspheres; drug delivery

PL

alginian; dekstran; nanocząstki; mikrosfery; dostarczanie leków

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2022
• Tom: Vol. 43, nr 3
• Strony: 405--–417
• Opis fizyczny: Bibliogr. 28 poz., rys., tab.

Twórcy

autor

Kulikowska-Darłak Aleksandra

• Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1 Street, 00-645 Warsaw, Poland

• https://orcid.org/0000-0002-0059-0667

autor

Stefanek Agata

• https://orcid.org/0000-0003-0015-3122

autor

Wasiak-Wojasińska Iga

• https://orcid.org/0000-0002-1832-4316

autor

Wiechecka-Ożdżyńska Paulina

• https://orcid.org/0000-0003-2778-2703

autor

Ciach Tomasz

• https://orcid.org/0000-0002-8726-8944

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