Synthesis and in vitro antimicrobial evaluation of amine substituted s-triazine based thiazolidinone/chalcone hybrids

• Autorzy: Shah D. R. , Lakum H. P. , Chikhalia K. H.
• Języki publikacji: EN

Abstrakty

EN

In an attempt to control multidrug resistant dilemma, a library of s-triazine based on two novel series of thiazolidinone (4a-e) and chalcone (7a-e) derivatives were designed and synthesized with simple and efficient etiquette. The newly synthesized compounds were studied for efficacy against several bacteria (Staphylococcus Aureus, Bacillus Cereus, Pseudomonas Aeruginosa, Klebsiella Pneumoniae,) and fungi (Candida Albicans, Aspergillus Clavatus) using the broth dilution technique. Compound 7d was the best bioactive desired antibacterial analogue with less MIC value against different tested strains. Results of bioassay study revealed the future hope of the potent drug-candidate based on s-triazine scaffold. All the final synthesized compounds were characterized by IR, ₁ H NMR, ₁₃ C NMR, mass and elemental analysis.

Słowa kluczowe

EN

Antibacterial; Antifungal; Chalcone; s-Triazine; 4-thiazolidinone

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 17, iss. 2
• Strony: 207--219
• Opis fizyczny: Bibliogr. 21 poz., rys., wz.

Twórcy

autor

Shah D. R.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed - 380009, Gujarat, India

autor

Lakum H. P.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed - 380009, Gujarat, India

autor

Chikhalia K. H.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed - 380009, Gujarat, India

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