Photoactivated titania-based nanomaterials for potential application as cardiovascular stent coatings

• Autorzy: Kopaczyńska M. , Sobieszczańska B. , Ulatowska-Jarża A. , Hołowacz I. , Buzalewicz I. , Wasyluk Ł. , Tofail S. A. M. , Biały D. , Wawrzyńska M. , Podbielska H.

Identyfikatory

DOI

10.1016/j.bbe.2014.03.005

• Języki publikacji: EN

Abstrakty

EN

Intravascular stenting of atherosclerotic coronary arteries is a life-saving, widely used procedure in interventional cardiology. Adverse clinical outcomes such as restenosis high-light the importance of meeting the excellent biocompatibility by cardiovascular implants. Many attempts have been made to improve the safety profile of implant surface. We for the first time developed the photoactive intravascular titania-based nanomaterials for the application as cardiovascular stent coating. Photoactive biomaterial deposited on the cardiovascular stent surface demonstrated promising features, making it an excellent substrate for endothelial cells growth and proliferation. The biocompatibility of these coatings has been compared with 316L stainless steel surfaces typically used in commercial coronary stents production. The results of the study proved that the innovative titania- based coatings have better biocompatibility characteristics than the 316L stainless steel and in regard of its antithrombotic potential provided protection against restenosis. Further-more, the titania coating supported endothelial cells attachment and proliferation, and induced prolonged plasma recalcification time in comparison with stainless steel surface. Innovative photoactive titania coating can be an important factor to prevent the process of the restenosis in the place of implantation.

Słowa kluczowe

EN

cardiovascular stent; photoactive coating; endothelial cells; surface charge; biocompatibility

PL

stent wieńcowy; komórka śródbłonka; ładunek powierzchniowy; biozgodność

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2014
• Tom: Vol. 34, no. 3
• Strony: 189--197
• Opis fizyczny: Bibliogr. 28 poz., rys., tab., wykr.

Twórcy

autor

Kopaczyńska M.

• Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

autor

Sobieszczańska B.

• Department of Microbiology, Wroclaw University of Medicine, Wrocław, Poland

autor

Ulatowska-Jarża A.

• Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wrocław, Poland

autor

Hołowacz I.

• Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wrocław, Poland

autor

Buzalewicz I.

• Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wrocław, Poland

autor

Wasyluk Ł.

• Balton Sp. Z o.o., Warsaw, Poland

autor

Tofail S. A. M.

• Materials and Surface Science Institute, University of Limerick, Ireland

autor

Biały D.

• Department and Clinic of Cardiology, Wroclaw University of Medicine, Wrocław, Poland

autor

Wawrzyńska M.

• Department of Medical Emergency, Wroclaw University of Medicine, Wrocław, Poland

autor

Podbielska H.

• Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wrocław, Poland

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