Delivery of nebulised drugs using endotracheal tube

• Autorzy: Penconek A. , Odziomek M. , Niedzielska A. , Moskal A.
• Języki publikacji: EN

Abstrakty

EN

The purpose of the studies was to estimate efficiency of delivering nebulised drugs into the lower respiratory tract through endotracheal tubes (ET tubes) which are commonly used in the treatment of uncooperative patients. Water solution of Disodium Cromoglycate (DSCG) was nebulised with a constant air flow (25 l/min). Experimental studies were done for eight ET tubes with varying sizes (internal diameter, length) and made of two different materials. Size distribution of aerosol leaving ET tubes was determined with the use of aerosol spectrometer. Fine Particle Fraction (FPF) and Mass Median Aerodynamic Diameter (MMAD) were calculated for the aerosol leaving each tube. Additionally, mass of the Disodium Cromoglycate deposited into each endotracheal tube was determined. ET tubes can significantly influence the parameters of delivered aerosol depending on their diameter. FPF of aerosol delivered in to the respiratory tract is lower if small endotracheal tubes are used. However, MMAD and FPF for large endotracheal tubes are almost identical with MMAD and FPF from nebuliser. The results indicate that a substantial fraction of large droplets is eliminated from the aerosol stream in long endotracheal tubes (270 mm). In this case the mass of drug delivered through ET tubes is reduced but the content of small droplets increases (high value of FPF).

Słowa kluczowe

EN

aerosol therapy; drug delivery; size distribution; deposition; endotracheal tube

PL

aerozoloterapia; rozkład wielkości; rurka intubacyjna

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2012
• Tom: Vol. 33, nr 4
• Strony: 689--696
• Opis fizyczny: Bibliogr. 14 poz., tab., rys.

Twórcy

autor

Penconek A.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

autor

Odziomek M.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

autor

Niedzielska A.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

autor

Moskal A.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

Bibliografia

• 1. Ahrens R.C, Ries R.A, Popendorf W, Wiese J.A., 1986. The delivery of therapeutic aerosols through endotracheal tubes. Pediatr. Pulmonol., 2, 19-26. DOI: DOI: 10.1002/ppul.1950020108.
• 2. Cook C.D., Sutherland J.M., Segal S., Cherry R.B., Mead J., McIlroy M.B., Smith C.A., 1957. Studies of respiratory physiology in the newborn infant. III Measurements of mechanics of respirations. J. Clin. Invest., 36, 440–448. DOI: 10.1172/JCI103441.
• 3. Dhand R., 2000. Special problems in aerosol delivery: Artificial airways. Respir. Care, 45, 636-645.
• 4. Gradoń L., Moskal A., Sosnowski T.R., 2007. Estimation of separation efficiencies of aerosol particles in the upper parts of a human respiratory tract. Chem. Process Eng., 28, 465-473.
• 5. Grigg J., Arnon S., Jones R., Clarke A., Silverman M., 1992. Delivery of therapeutic aerosols to intubated babies. Arch. Dis. Child., 67, 25-30. DOI: 10.1136/adc.67.1_Spec_No.25.
• 6. Heyder J., 2004. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc. Am. Thorac. Soc., 1, 315–320. DOI: 10.1513/pats.200409-046TA. Hickey A.J., 1993. Lung deposition and clearance of pharmaceutical aerosols: What can be learned from
• 7. inhalation toxicology and industrial hygiene? Aerosol Sci. Technol., 18, 290-304. DOI: 10.1080/02786829308959606.
• 8. MacIntyre N.R, Silver R.M, Miller C.W, Schuler F., Coleman R.E., 1985. Aerosol delivery in intubated, mechanically ventilated patients. Crit. Care Med., 13, 81-84.
• 9. Mazela J., Sosnowski T.R., Moskal A., Gadzinowski J., 2011. Small neonatal ET Tube sizes decrease aerosol penetration - Computational Fluid Dynamics study. Respiratory Drug Delivery Europe 2011, Berlin, Germany, 2-6 May 2011, 2, 401-404.
• 10. Schueepp K.G., Devadason S.G., Roller Ch., Minoccheieri S., Moeller A., Hamacher J., Wildhaber J. H., 2009. Aerosol delivery of nebulised budesonide in young children with asthma. Respir. Med., 103, 1738-1745. DOI: 10.1016/j.rmed.2009.04.029.
• 11. Sosnowski T.R., 2010. Inhalable aerosols and inhalers. WIChiP PW, Warsaw University of Technology, 14 (in Polish).
• 12. Watterberg K., Clark A., Kelly H.W., Murphy S, 1991. Delivery of aerosolized medication to intubated babies. Pediatr. Pulmonol., 10, 136-141. DOI: 10.1002/ppul.1950100217.
• 13. Zanen P., Go L.T., Lammers J.J., 1995. The optima particie size for parasympathicolytic aerosols In mild asthmatics, Int. J. Pharmaceutics, 114, 111-115. DOI: 10.1016/0378 5173(94)00224-S.
• 14. Żywczyk Ł., Moskal A., Sosnowski T.R., 2010. Badanie depozycji cząstek aerozolowych w rurkach dozujących (Endotracheal tube) stosowanych podczas podawania leków. Inż. Aparat. Chem., 49, 125-126.