Badania czynnościowe mózgu jako metoda diagnostyki przedoperacyjnej u chorych operowanych z powodu padaczki opornej na leczenie farmakologiczne

• Autorzy: Wolak T. , Szymańska O. , Soluch P. , Szeszkowski W. , Kurjata R. , Orzechowski M. , Bogorodzki P. , Piątkowska-Janko E. , Marchel A. , Rysz A. , Majkowska-Zwolińska B.
• Konferencja: Sympozjum Inżynieria Biomedyczna i Telemedyczna (8-9.09.2006; Warszawa, Polska)
• Języki publikacji: PL

Abstrakty

EN

For patients with pharmacoresistant epilepsy only surgieal intervention is an effeetive solution. To prevent unnecessary damage of important regions of the brain, there is a need for mapping of funetional organization of cerebral cortex. In cIinical practiec together with neuropsyehological evaluation an invasive techniques are used: intraoperative cortex mapping using electrieal stimulation and Wada test. In this work, usefulness of fMRI in preoperative planning for those patients was assessed. In cooperation with group of neuropsyehologists five patients were studied. A group of tests was prepared eonsisting of phonetie and semantic fIueney for Broea mapping and a group of motoric tests. All experiments were performed on two seanners for repeatability assessment. For each patient individual maps of active regions were eaculated using SPM2 package and self made tools. For verification of results cIinical evaluation methods were used: Wada test comparison, comparison with intraoperative stimulation and spatial relations between lesions and functional regions. Three of five patients had surgical intervention. None of them presented any degradation in most endangered function - verbal for 2 patients and motoric in one case. All patients will be examined after 6 months. At current stage of study a cIinical protocol is being designed for routine use.

Słowa kluczowe

PL

funkcjonalny rezonans magnetyczny; epilepsja; test Wada

• Wydawca: Oficyna Wydawnicza Politechniki Warszawskiej
• Czasopismo: Prace Naukowe Politechniki Warszawskiej. Elektronika
• Rocznik: 2006
• Tom: z. 157
• Strony: 19--25
• Opis fizyczny: Bibliogr. 18 poz., wykr., tab., rys.

Twórcy

autor

Wolak T.

autor

Szymańska O.

autor

Soluch P.

autor

Szeszkowski W.

autor

Kurjata R.

autor

Orzechowski M.

autor

Bogorodzki P.

autor

Piątkowska-Janko E.

autor

Marchel A.

autor

Rysz A.

autor

Majkowska-Zwolińska B.

• Instytut Radioelektroniki Politechniki Warszawskiej Warszawa Polska

Bibliografia

• [1] Penfield W.: Technique of Excision of Epileptogenic Focus. Cortical stimulation. W: Epilepsy and the Functional Anatomy of the Human Brain. Penfield W., Jasper H. ed., London, 1954, 761-765.
• [2] Wada J., Rasmussen T.: Intracarotid injection of sodium Amytal for the lateralization of cerebral speech dominance: experimantal and clinical observation. J. Neurosurg., 1960, 17, 266-282.
• [3] Deblaere K., Backes H.W., Hofman P., Vandemaele P., Boon P.A., Yonck K., Troost J., Vermeulen J., Wilmink J., Achten E., Aldenkamp A.P.: Developing a comprehensive presurgical functional MRI protocol for patients with intractable temporal lobe epilepsy: a pilot study. Neuroradiology 2002, 44, 667-673.
• [4] McDermott K.B., Petersen S.E., Watson J.M., Ojemann J.G.: A procedure for identyfying regions preferentially activated by attention to semantic and phonological relations using functional magnetic resonance imaging. Neuropsychologia 2003, 41, 293-303.
• [5] Janszky J., Ollech I., Jokeit H., Kontonopulou K., Mertens M., Pohlmann-Eden B., Ebner A., Woermann F.G.: Epileptic activity influences the lateralization of mesiotemporal fMRI activity. Neurology 2004, 63, 1813-1817.
• [6] Richardson M.P., Strange B.A., Thompson P.J., Baxendale S.A., Duncan J.S., Dolan R.J.: Pre-operative verbal memory fMRI predicts post-operative Memory decline after left temporal lobe resection. Brain 2004, 127, 2419-2426.
• [7] Abou-Khalil B.W.: How Close is fMRI to Providing the Memory Component of the Wada Test? Epilepsy Currents 2005, 5(5), 184-186.
• [8] Aldenkamp A.P., Boon P.A., Deblaere K., Achten E., Backes H.W., Boon P., Hofman P., Troost J., Vandemaele P., Vermeulen J., Vonck K., Wilmink J.: Usefulness of language and memory testing during intracarotid amobarbital testing: observation from an fMRI study. Acta Neurol. Scand. 2003, 108, 147-152.
• [9] Baciu M.V., Watson J.M., Maccotta E., McDermott K.B., Buckner R.L., Gilliam F.G., Ojemann J.G.: Evaluating functional MRI procedures for assessing hemispheric language dominance in neurosurgical patients. Neuroradiology 2005, 47(11), 835-844.
• [10] Tomaszewki Farias S., Harrington G, Broomand C, Seyal M. Differences in Functional MR Imaging Activation Patterns Associated with Confrontation Naming and Responsive Naming. American Journal of Neuroradiology 2005, 26, 2492-2499.
• [11] Bogorodzki P., Rogowska J., Yurgelun-Todd D.A.: Structural Group Classification Technique based on Regional fMRI BOED Responses. IEEE Trans. Med. Imaging., 2005, 24 (3), 389-98.
• [12] Buxton R.: Introduction to Functional Magnetic Resonance Imaging, Cambridge University Press, 2002.
• [13] Brodmann, K. Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues, Leipzig: J.A. Barth 1909.
• [14] Wellmer J., Fernandez G., Linke D.B., Urbach H., Elger C.E., Kurthen M.: Unilateral Intracarotid Amobarbital Procedure for Language Lateralization. Epilepsia 2005, 46 (11) 1764-1772.
• [15] Woods R.P., Dodrill C.B., Ojemann G.A.: Brain injury, handedness, and speech lateralization in a series of amobarbital studies. Ann. Neurol. 1988, 23 (5), 510-518.
• [16] Devinsky O., Perrine K., Llinas R., Luciano D.J., Dogali M.: Anterior Temporal Language Areas in Patients with Early Onset of Temporal Lobe Epilepsy. Ann. Neurol.1993, 34, 727-732.
• [17] Miller J.W., Dodrill C.B., Born D.E., Ojemann G.A.: Atypical speech is rare in individuals with normal developmental histories. Neurology 2003, 60 (6), 1042-144.
• [18] Woermann F.G., Jokeit H., Luerding R., Freitag H., Schulz R., Guertler S., Okujava M., Wolf P., Tuxhorn I, Ebner A.: Language lateralization by Wada test and fMRI in 100 patients with epilepsy. Neurology 2003, 61, 699-701.