Effect of storage time on microwave saturation of EPR spectra of thermally sterilized streptomycin and its practical applications

• Autorzy: Ramos P. , Pilawa B. , Bernaś M.
• Języki publikacji: EN

Abstrakty

EN

Electron paramagnetic resonance spectroscopy at X-band (9.3 GHz) is used as the tool of optimalization of storage of thermally sterilized aminoglycoside antibiotic - streptomycin. Thermal sterilization at different conditions was performed according to the norms. Changes in free radicals system of this drug during storage after sterilization were detected. Lineshape analysis and microwave saturation of EPR spectra were done. Free radical concentrations were determined. Microwave saturation EPR analysis is proposed as useful method to determine the best conditions of storage of sterilized drugs.

Słowa kluczowe

EN

EPR spectra; microwave saturation; free radicals; streptomycin; thermal sterilization

PL

spektroskopia elektronowego rezonansu paramagnetycznego; nasycenie mikrofalowe; wolne rodniki; streptomycyna; sterylizacja prądu termicznego

• Wydawca: University of Silesia, Institute of Informatics, Computer Systems Department
• Czasopismo: Journal of Medical Informatics & Technologies
• Rocznik: 2010
• Tom: Vol. 15
• Strony: 185--191
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Ramos P.

• Department of Biophysics, School of Pharmacy and Division of Laboratory Medicine, Jedności 8, 41-200 Sosnowiec, Medical University of Silesia in Katowice

autor

Pilawa B.

autor

Bernaś M.

Bibliografia

• [1] JNICKI S., FIEBIG A., Farmacja stosowana, PZWL, Warszawa, 1998.
• [2] RAMOS P., Free radicals in aminoglycoside and β–laktame antibiotics, Doctoral Thesis, Silesian Medical University in Katowice, Katowice 2009.
• [3] PILAWA B., RAMOS P., WILCZYŃSKI S., CZYŻ K., Free radicals system analysis for thermally sterilized diclofenac. Engineering of Biomaterials, XI(81–84), 2008, pp. 57–58.
• [4] KOŚCIELNIAK M., WILCZYŃSKI S., PILAWA B., Free radicals in thermally sterilized prednizolone. Engineering of Biomaterials, XI(81–84), 2008, pp. 61–62.
• [5] PILAWA B., RAMOS P., WILCZYŃSKI S., ADAMCZYK J., Relaksacja spin–sieć w sterylizowanej termicznie streptomycynie i ampicylinie. XLI Ogólnopolskie Seminarium na Temat Magnetycznego Rezonansu Jądrowego i Jego Zastosowań, Instytut Fizyki Jądrowej im. H. Niewodniczańskiego Polskiej Akademii Nauk, Kraków, 1–2 grudnia 2008, (abstracts: www.ifj.edu.pl/conf/mrj08/abstrakty.html). (in Polish).
• [6] BARTOSZ G., Druga twarz tlenu, PWN, Warszawa, 2004, (in Polish).
• [7] JÓŹWIAK Z., BARTOSZ G., Biofizyka, PWN, Warszawa, 2005, (in Polish).
• [8] KOSTOWSKI W., HERMAN S. Z., Farmakologia, PZWL, Warszawa, 2007, (in Polish).
• [9] ZEJCA A., Chemia leków, PZWL, Warszawa, 2004, (in Polish).
• [10] PN–EN 556. Sterylizacja wyrobów medycznych. Wymagania wyrobów medycznych określanych jako sterylne, (in Polish).
• [11] Farmakopea polska wydanie VIII. PTFarm, Warszawa, 2009, (in Polish).
• [12] WERTZ JE, BOLTON JR. Electron Spin Resonance Theory and Practical Applications. New York, London; 1986.
• [13] HOFFMANN SK, HILCZER W, KEMPIŃSKI W, STANKOWSKI J. Electron spin echo and EPR studies of paramagnetic center in polycrystalline C60. Solid State Commun, Vol. 93, 1995, pp. 197–202.
• [14] EATON GR, EATON SS, SALIKHOV KM, eds. Foundations of modern EPR, World Scientific, Singapore, New Jersey, London, Hong Kong 1998.