Estimation of significance of AlkB and AlkA proteins in DNA repair in Escherichia coli model

• Autorzy: Sokołowska B. , Maciejewska A. M. , Jóźwik A. , Kuśmierek J. T.
• Języki publikacji: EN

Abstrakty

EN

The paper concerns estimation of significance of differences of mutagenesis level between the wild-type strain (wt) and its derivatives which differ in DNA repair ability, namely alkA and alkB strain, devoided AlkA glycosylase and AlkB dioxygenase activity, respectively. The strains were analyzed for their ability to repair 1,N6-ethenoadenine (εA) - chloroacetaldehyde adduct to DNA. The analysis was done using classical statistical and pattern recognition methods. The obtained results confirmed that AlkB dioxygenase plays the most important role in εA repair in E. coli in the experimental modeling.

Słowa kluczowe

EN

pattern recognition; fuzzy k-NN classifier; ROC analysis; DNA repair; adaptive response; mutagenesis; AlkB dioxygenase; AlkA glycosylase; E.coli

PL

rozpoznawanie obrazów; klasyfikator najbliższych sąsiadów; analiza cech pracy odbiornika; naprawa DNA; adaptacyjna odpowiedź; powstawanie mutacji; bakterie e.coli

• Wydawca: University of Silesia, Institute of Informatics, Computer Systems Department
• Czasopismo: Journal of Medical Informatics & Technologies
• Rocznik: 2011
• Tom: Vol. 17
• Strony: 321--326
• Opis fizyczny: Bibliogr. 29 poz., rys., tab.

Twórcy

autor

Sokołowska B.

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

autor

Maciejewska A. M.

autor

Jóźwik A.

autor

Kuśmierek J. T.

Bibliografia

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