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The influence of bone tissue microstructure' parameters on bone mineral density parameter computed within the computer simulation process

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Języki publikacji
EN
Abstrakty
EN
The given article was created with reference to lack of correlation between results from densitometry test of bone tissue and its mechanical strength. The changes of bone mechanical strength cannot be solely connected with changes of bone mineral density with micro structural construction of bone tissue. The article describes the research using a computer simulation where changes of physical density and parameters of bone microstructure were modelled. The influences of those parameters for changing the bone mineral density have been computed. It has been calculated during simulation process similar to the way it has been provided from densitometry test. The computation process has been carried out on the basis of computer method of simulation of x-ray radiation propagating through the object and had been was created and tested in the previous research. The model of tested object was defined by spatial high resolution distribution of density. The simulation was executed on a sample of bone tissue. The input data to the model of sample were series of cross-sections obtained previously from micro CT of an animal sample. The changes of parameters were simulated in the model based on a method of 2D image processing. The procedure was used to reduce the trabecular surface for all cross-sections. The results of the algorithm were measured during algorithm process. Images were also analyzed by software to measure parameters of microstructure. It gave a chance to estimate the correlation between measured parameter and parameters of microstructure. The applied method of simulation of attenuation of x-ray radiation allowed to produce densitometry image and to compute parameter similar to bone mineral density. The analysis of obtained results shows how the bone mineral density computed from simulation depends on changes of parameters of microstructure.
Rocznik
Tom
Strony
49--55
Opis fizyczny
Bibliogr. 18 poz., rys., tab.
Twórcy
autor
  • Institute of Computer Science, Silesian University, Department of Biomedical Computer Systems Poland, 41-200 Sosnowiec, ul. Będzińska 39
  • Institute of Computer Science, Silesian University, Department of Biomedical Computer Systems Poland, 41-200 Sosnowiec, ul. Będzińska 39
  • Laboratory of Biotechnology, Poland, 43-400 Cieszyn, ul. Goździków 2
  • Silesian Hospital in Cieszyn, Poland, 43-400 Cieszyn, ul. Bielska 4
autor
  • Institute of Computer Science, Silesian University, Department of Biomedical Computer Systems Poland, 41-200 Sosnowiec, ul. Będzińska 39
Bibliografia
  • [1] BADURSKI J., SAWICKI A., BOCZOŃ S.: The Osteoporosis., Osteoprint, Białystok, 1994
  • [2] BĘDZIŃSKI R., Biomechanics – engineering, the current issiue. Oficyna Wydawnicza Politechniki Wrocławskiej, 1997 Wrocław.
  • [3] BINKOWSKI M., WRÓBEL Z.: Modal techniques in biomedical objects analysis, Journal of Medical and Technologies, vol. 2/2001, ISSN 1642-6037, pp. MT-93-99.
  • [4] BINKOWSKI M., WRÓBEL Z., DYSZKIEWICZ A.: Application of modal analysis in diagnosis of mechanical properties of bone tissue. Acta of Bioengineering and Biomechanics. 13th Conference of European society of Biomechanics. Oficyna Wydawnicza Politechniki Wrocławskiej, Wrocław., 1-4.09.2002, pp. 408-410.
  • [5] BINKOWSKI M., WRÓBEL Z., DYSZKIEWICZ A.: The Parameters of Density and Mechanical Strength of Bone Tissue in Diagnosis of Susceptibility to Fracture., Conference Materials from Fifth Symposium on Medical Modeling and Measurement., AGH, Krynica, Poland, May 2003. pp. 211-216
  • [6] BINKOWSKI M., WRÓBEL Z., DYSZKIEWICZ A.: The changes caused by modification of biomechanical properities of a bone., Medical and Care Compunetics 1., International Congress Medical and Care Compunetics 2004., IOS Press, Amsterdam, Holland., pp. 12-18.
  • [7] BOYLE IT. Secondary osteoporosis. Baillleres Clin Rheumatol 1993; 7: 515-34.
  • [8] BURGER H., de LAET C.E., i wsp.: Risk factors for increased bone loss in an elderly population: the Rotterdam Study, Am. J. Epidemiol., 1998., 147, 871-9
  • [9] CZERWIŃSKI E., DZIAŁAK P.: The diagnostic of osteoporosis and estimation of fracture risk., Ortopedia Traumatologia Rehabilitacja, 2002, Vol. 4, Nr 2, 127-134.
  • [10] GĄDEK A., WOJNAR L., CZERWIŃSKI E.: Effect of histomorphometric parameters on compression strength of vertebral bodies., Image Analysis Stereology., 2001., 20., ss. 35-39.
  • [11] GMIŃSKI J.: Raloksyfen – a new perspectiv of osteoporosis treatment, Annales Academiae Medicae Silesiensis, Monografia Tematyczna IV Śląskie Sympozjum Chorób Tkanki Kostnej, Ustroń 2002, Supl. 47, 83-93.
  • [12] KANIS J. A., GLUER C.C. I wsp.: An update on the diagnosis and assessment of osteoporosis with densitometry, Osteoporosis Int., 2000, 11, 192-202
  • [13] NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy.: Osteoporosis prevention, Diagnosis, and Therapy, JAMA 2001, 285, 785-795.
  • [14] NOWAK .A., BADURSKI., J.E. i wsp.: Białystok Osteoporosis Study (BOS): Epidemiology of low trauma fractures in the female population., Osteoporosis Int., 2001., 12 Suppl.,1,L03
  • [15] NIGEL K. ARDEN i TIMOTHY D. Spector, Osteoporoza aktualny stan wiedzy, Red. polskiego wydania Badurski Janusz E., Wydawnictwo Medyczne Borgis, Warszawa 2000
  • [16] RUIMERMAN R., HILBERS P., van RIETBERGEN B., HUISKES R., Mechanical regulation of bone cell metabolism and structural adaptation in trabecular architecture., Acta of Bioengineering and Biomechanics., Volume 4., Supplement 1, 2002., 13th Conference of European Society of Biomechanics, 1-4.09.2002, Wrocław.
  • [17] HRYNKIEWICZ A.Z, ROKITA E.., Phisycal methods of medical diagnosis and therapy., PWN. Warszawa 2000 pp. 64-68.
  • [18] DYSZKIEWICZ A., WRÓBEL Z., “Simulation of the reaction of x-ray radiation with an object whithin densitometry test.”, Binkowski M., Journal of Medical Informatics & Technologies Vol. 8/2004, ISSN 1642-6037, pp. MM-95-104.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-PWA4-0012-0004
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