Pattern recognition approach to differentiation of disease severity in patients with amyotrophic lateral sclerosis

• Autorzy: Jóźwik A. , Sokołowska B. , Niebroj-Dobosz I. , Janik P. , Kwieciński H.
• Języki publikacji: EN

Abstrakty

EN

A possibility of recognition of the clinical status of patients with amyotrophic lateral sclerosis (ALS) in relation to severity of the disease was investigated. Three groups: (i) healthy controls (n=15) and two subgroups of ALS patients (ii) mild (n=15) and (iii) severe (n=15) were considered as classes. Four features of the subjects: (i) their age (AGE) (ii) erythropoietin concentration in serum (SERUM), (iii) in cerebrospinal fluid (CSF), and (iv) duration time of the disease (Tdis) were used for classifier construction based on the k Nearest Neighbours (k-NN) rule, known from pattern recognition theory. The presented results demonstrate that the pattern recognition approach may be useful for the evaluation of the severity of the ALS disease.

Słowa kluczowe

EN

pattern recognition; k-NN classifier; amyotropic lateral sclerosis; erythropoietin

PL

rozpoznawanie obrazu; klasyfikacja K-NN; erytropoetyna

• Wydawca: University of Silesia, Institute of Informatics, Computer Systems Department
• Czasopismo: Journal of Medical Informatics & Technologies
• Rocznik: 2008
• Tom: Vol. 12
• Strony: 143--147
• Opis fizyczny: Bibliogr. 11 poz., rys., tab.

Twórcy

autor

Jóźwik A.

• Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Sokołowska B.

autor

Niebroj-Dobosz I.

autor

Janik P.

autor

Kwieciński H.

Bibliografia

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• [6] DUDA R.O., HART P.E., STOCK D.G., Pattern Classification. John Wiley and Sons, New York, 2001.
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• [8] GRUNFELD J.F., BARHUM Y., BLODHEIM N. et al., Erythroietin delays disease onset in an amyothropic lateral sclerosis model, Experimental Neurology, Vol. 204, pp.260-263, 2007.
• [9] JANIK P., KWIECIŃSKI H., NIEBROJ-DOBOSZ I., Erythropoietin concentration in serum and cerebrospinal fluid of patients with amyotropic lateral sclerosis (ALS), in press.
• [10] ROWLAND L.P., SHNEIDER N.A., Amyotrophic Lateral Sclerosis, New England Journal of Medicine, Vol. 344, No. 22, pp.1688-1700, 2001.
• [11] WIDL K., BRETTSCHNEIDER J., SCHATTAUER D. et al., Erythropoietin in cerebrospinal fluid: Age-related reference values and relevance in neurological disease, Neurochemical Research, Vol.32, pp.1163-1168, 2007.