Thyroid hormone and thyreotropin (TSH) association with densitometric parameters in children

• Autorzy: Porwik E. , Matusik P. , Drzyzdzyk K.
• Języki publikacji: EN

Abstrakty

EN

The influence of TSH on bones is still vastly unknown and the information that is known is considered controversial. This important relationship has not been studied in detail. The aim of our research was to assess the correlation between TSH, thyroid hormone and bone mineral density in children measured by DXA scanning. Our study group included 36 children (16 girls and 20 boys) mean age 12.9 š 3.3 years. Basic anthropometrical measurements were performed (height, weight, body mass index-BMI), in all subjects. Blood was collected and measured for TSH and FT4. Bone mineral density of lumbar spine (L2-L4 BMD) and total body (Total Body BMD) were measured by DXA and expressed as bone mineral content (BMC [g]) and bone mineral density (BMD [g/cm2]). BMD Z-Score was also calculated. Correlation between the parameters obtained by DXA and anthropometrical data, TSH and thyroid hormone concentration were calculated. A statistically significant positive correlation was observed between height, weight and BMI and BMD which was calculated. Weight and BMI also had a statically significant correlation with Z-Score and total bone mineral content (BMC – expressed in grams). There was a statistically significant positive correlation between TSH level and Z-Score for both L2-L4 lumbar spine and for total body. TSH did not correlate significantly with BMD [g/cm2] and BMC [g]. FT4 was negatively and significantly correlated with Z-Score for both L2-L4 lumbar spine and for total body. There was also no significant correlation between FT4 and BMD [g/cm2] and BMC [g]. Conclusion: 1. Thyroid stimulating-hormone (TSH) appears to be associated with maintenance of bone mineral density in children. 2. BMD Z-Score especially from L2-L4 lumbar spine assessed by DXA scanning is correlated best with hormonal and biochemical factors potentially influencing bone mineralization in children.

Słowa kluczowe

EN

thyrotropin; thyroid hormone; densitometry; bone mineral density; children

PL

tyreotropina; hormon tarczycy; densytometria; gęstość mineralna kości; dziecko

• Wydawca: University of Silesia, Institute of Informatics, Computer Systems Department
• Czasopismo: Journal of Medical Informatics & Technologies
• Rocznik: 2009
• Tom: Vol. 13
• Strony: 141--144
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Porwik E.

• Postgraduate student. Scientific Society of Medical Students, Medical University of Silesia, Katowice, ul. Medyków 18, Poland

autor

Matusik P.

autor

Drzyzdzyk K.

Bibliografia

• [1] ABE E., MARIANS R.C., YU W., WU X.B., ANDO T., LI Y., IQBAL J., ELDEIRY L., RAJENREN G., BLAIR H.C., DAVIES T.F., ZAIDI M., TSH is a negative regulator of skeletal remodeling. Cell, 2003, vol. 115, pp. 151-162.
• [2] BARONCELLI G.I., BERTELLONI S., SONDINI F., Lumbar bone mineral density at final height and prevalence of fractures in treated children with GH density. J Clin Endocrinol Metab., 2002, vol. 87, pp. 3624- 3631.
• [3] BASSETT JHD., WILLIAMS GR., Critical role of the hypothalamic-pituitary-thyroid axis in bone. Bone, 2008, vol. 43, pp. 418-426.
• [4] BASSETT J.H.D., WILLIAMS A.J., MUTPHY E., BOYDE A., HOWELL PGT., SWINHOE R., ARCHANCO M., FLAMANT F., SAMARUT J., COSTAGLIOLA S., VASSART G., WEISS RE., REFETOFF S., WILLIAMS GR., A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism. Molecular Endocrinology ,2008, vol. 22, pp. 501-512.
• [5] BIANCHI M.L, MAZZANTI A., GALBIATI E., Bone- mineral density and bone metabolism in Duchenne muscular dystrophy. Osteoporosis Int., 2003, vol. 14, pp. 761-767.
• [6] BINKOVITZ L.A., SPARKE P., HENWOOD MJ., Pediatric DXA: clinical applications. Pediatr Radiol., 2007, 37, pp. 625-635.
• [7] BONJOUR JP., THEINTZ G., BUCHS B., SLOSMA B., RIZZOLI R., Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocirinol Metab.,1991, vol. 73, pp. 555-5635.
• [8] GILSANTZ V., GIBBENS DT., ROE TF., et al. Vertebral bone density in children: effect of puberty. Radiology 1988, vol. 166, pp. 847-850.
• [9] GREENSPAN SL., GREENSPAN FS., The effect of thyroid hormone on skeletal integrity. Ann Intern Med.,1999, vol. 130, pp. 750-758.
• [10] HEAP J., MURRAY M.A., MILLER S.C., JALILI T., Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus. J Pediatr., 2004, vol. 144, pp. 56-62.
• [11] HEEMSTRA K.A., VAN DER DEURE W.M., PEETERS R.P., HAMDY N.A., STOKKEL M.P., CORSSMIT E.P., ROMIJN J.A., VISSER T.J., SMIT J.W., Thyroid hormone independent association between serum TSH level and indicators of bone turnover in cured patients with differentiated thyroid carcinoma. European Journal of Endocrinology, 2008, vol. 159, pp. 69-76.
• [12] INOUE M., TAWATA M., YOKOMORI N., ENDO T., ONAYA T., Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cells. Thyroid 1998, vol. 8, pp. 1059-1064.
• [13] JANUSZEWICZ W., KOKOT., Interna, Warszawa 2006, t.2, pp. 1230-1232.
• [14] MALECKA-TENDERA E., MATUSIK P., FRANEK E., KLIMEK K., Correlation of lumbar bone mineral density with age, height and body mass in pubertal girls. Endokrynol Pediatr.,2002, vol. 1, pp. 9-15.
• [15] MC DERMOTTM MT., PERLOFF JJ., KIDD GS., A longitudinal assessment of bone loss in women with levothyroxine-suppresed benign thyroid disease and thyroid cancer. Calcif Tissue Int.,1995, vol. 56, pp. 521-525.
• [16] MORA S., BARERA G., BECCIO S., A prospective, longitudinal study of the long- term effect of treatment on bone density in children with celiac disease. J Pediatr., 2001, vol. 139, pp.516-521.
• [17] MOSKELIDE L., Sex differences in age-related loss of vertebral trabecular bone mass and structure: biomechanical consequences. Bone,1989, vol. 10, pp. 425-432.
• [18] VON RECKLINGHAUSEN F.D. Die Fibrose oder deformierende Ostitis, die Osteomalazie und die osteoplastiche Carzinose in ihren gegenseitigen Beziehungen. (Osteitis fibrosa or deformans, osteomalacia and osteoplastic carcinosis in their relationships) Berlin: George Reimer ; 1891,1.
• [19] REIMER G., Osteoplastiche Carzinose in ihren gegenseitigen Beziehungen. (Osteitis fibrosa or deformans, osteomalacia and osteoplastic carcinosis in their relationships.) Berlin, 1891,1.
• [20] SENDAK R.A., SAMPATH T.K., MCPHERSON J.M., Newly reported roles of thyroid-stimulating hormone and folliclestimulating hormone in bone remodeling. Int Orthop., 2007, vol. 31, pp.753-757.
• [21] SOYKA L.A., MISRA M., FRENCHMAN A., Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab., 2002, vol. 87, pp. 44177- 44185.
• [22] SUN L., DAVIES TF., BLAIRl HC., ABE E., ZAIDI M., TSH and bone loss. Ann NY Acad Sci. 2006, vol. 1068, pp. 309-318.
• [23] WARD L.M., GLORIEUXl F.H., The spectrum of pediatric osteoporosis. In: Glorieux FH, Pettifor JM, Juppner H (eds). Pediatric bone: biology and diseases. San Diego: Academic Press, 2003, pp. 401-442.
• [24] WHYTE M.P. Osteogenesis imperfecta. In: Favus M (ed). Primer on metabolic diseases and disorders of mineral metabolism. Washington: American Society for Bone and Mineral Research, 2003, pp. 470-473.
• [25] ZOFKOVA I, HILL M. Biochemical markers of bone remodeling correlate negatively with circulating TSH in postmenopausal women. Endocr Regul 2008, vol. 42, pp. 121-127.