Ibuprofen-tyrosine (Val-Tyr, Val-Tyr-Val) interactions. Theoretical and experimental studies

• Autorzy: Kowalska-Baron A. , Brychtova M. , Petrovic I. , Passos Sene I. , Quinones P. , Sogorkova J.
• Języki publikacji: EN

Abstrakty

EN

In this work, the interactions between ibuprofen and tyrosine as well selected tyrosine-containing oligopeptides (Val-Tyr, Val-Tyr-Val) have been studied using both experimental (absorption and fluorescence spectroscopy) and theoretical (the PM3 method) techniques. The experimentally obtained values of association constant together with free Gibbs energy of association for the studied tyrosine-ibuprofen and Val- Tyr-; Val-Tyr-Val-ibuprofen complexes have been determined. The obtained results indicated that the mechanism of action of ibuprofen is most probably based on the hydrogen bonding interaction which involves hydroxyl group of tyrosine.

Słowa kluczowe

EN

ibuprofen; hydrogen bonding interactions; PM3 calculations

PL

ibuprofen; wiązania wodorowe

• Wydawca: Wydawnictwo Politechniki Łódzkiej
• Czasopismo: Biotechnology and Food Science
• Rocznik: 2011
• Tom: Vol. 75, nr 2
• Strony: 15--26
• Opis fizyczny: Bibliogr. 11 poz.

Twórcy

autor

Kowalska-Baron A.

autor

Brychtova M.

autor

Petrovic I.

autor

Passos Sene I.

autor

Quinones P.

autor

Sogorkova J.

• Institute of General Food Chemistry, Faculty of Biotechnology and Food Science, Technical University of Lodz, 90-924 Lodz, Poland,

Bibliografia

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