The ions' channels conditioning the biological function of Lupinus luteus ferritin

• Autorzy: Gajda J. , Smól J. , Twardowski T.

Warianty tytułu

PL

Wpływ kanałów jonowych na biologiczną funkcję ferrytyny

• Języki publikacji: PL

Abstrakty

PL

Badanie procesu uwalniania żelaza z ferrytyny jest bardzo ważne z punktu widzenia biologicznej funkcji tego białka roślinnego. Rola ferrytyny łubinowej polega na gromadzeniu i przechowywaniu żelaza w osłonie proteinowej oraz na uwalnianiu go w razie potrzeb organizmu. Żelazo wnika do środka ferrytyny dzięki obecności w jej płaszczu białkowym kanałów jonowych. Dlatego też w pracy tej zaproponowano prosty model kinetyczny migracji jonów Fe2+ przez kanał oparty na elektrodyfuzyjnym równaniu Nernsta-Planca. Zgodnie z założeniami tego modelu obserwujemy różnicę pomiędzy stałą szybkości migracji jonów żelaza(II) do wnętrza powłoki białkowej ze stałą szybkości dyfuzji tych jonów na zewnątrz białka. W odniesieniu do zaprezentowanego modelu kinetycznego różnicę tę można wytłumaczyć rozkładem pola elektrycznego wzdłuż kanałów jonowych oraz silnym wpływem obdarzonych ładunkiem indywiduów chemicznych.

EN

The investigation of iron release from the ferritin core became very important for our understanding of the biological function of lupine ferritin: protection of the environment against heavy metal ions and supplementing the biological systems with iron. Therefore we propose a simple model of Fe2+ ions migration through the channel. This model is based on the Nernst-Planck electrodiffusion equation. According to this model we observed differences between the constant rate for uptake kuptake and constant rate for release Krelease. This observation can be explained by the control of migration of Fe2+ ions through the channels via distribution of electric field around them and it is strictly controlled by the charged individuals.

Słowa kluczowe

PL

żelazo; uwalnianie żelaza; równanie Nernsta-Plancka

EN

iron; iron release; Nernst-Planck equation

• Wydawca: Wydawnictwo Politechniki Łódzkiej
• Czasopismo: Zeszyty Naukowe. Chemia Spożywcza i Biotechnologia / Politechnika Łódzka
• Rocznik: 2005
• Tom: Z. 69
• Strony: 5--22
• Opis fizyczny: Bibliogr. 42 poz.

Twórcy

autor

Gajda J.

• Technical University of Łódź

autor

Smól J.

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań

autor

Twardowski T.

• Technical University of Łódź
• Polish Academy of Sciences, Poznań

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