Some aspects of numerical modeling of temperature increase due to ultrasound beam irradiation of rat liver

• Autorzy: Kruglenko E. , Gambin B.
• Języki publikacji: EN

Abstrakty

EN

Some aspects of FEM modeling of hyperthermia, the procedure of tissue temperature rise above 37 oC inside the living organism, as a treatment modality, are studied. Low intensity focused ultrasound (LIFU) beam has been used as a source of temperature rise in the liver tissue during performed experiments in vitro. The comparison of the FEM model of the corresponding heating process and the experimental results has been presented in [1]. In the paper, the FEM model of heating scheme of the rat liver tissue in vivo irradiated by the same ultrasound transducer is formulated. At first, the existence of blood perfusion is taken into account in the model equation. Secondly, the thermal and acoustical properties, which are the input parameters of the numerical model, are taken from the published data in literature. Here, the size and the intensity of heat sources are modeled in two ways on the basis of acoustic nonlinear equation solutions in 3 layers attenuating medium. We demonstrate how the results of FEM model in the case of in vitro and in vivo heating, depend on the assumed power density of heat sources, as well as on the size of the heated area. The results are compared and discussed. The influence of different models on temperature rise profiles are demonstrated.

• Wydawca: Polskie Towarzystwo Akustyczne. Oddział Gdański
• Czasopismo: Hydroacoustics
• Rocznik: 2011
• Tom: Vol. 14
• Strony: 99--110
• Opis fizyczny: Bibliogr. 8 poz., rys., tab.

Twórcy

autor

Kruglenko E.

autor

Gambin B.

• Institute of Fundamental Technological Research, Polish Academy of Sciences 5B, Pawińskiego St., 02-106 Warsaw, Poland,

Bibliografia

• [1] Gambin B., Kujawska T., Kruglenko E., Mizera A., Nowicki A., Temperature Field Induced by Low Power Focused Ultrasound on Soft Tissues During Gene Therapy, Numerical Predictions and Experimental Results, Archives of Acoustics, 34, 4, (2009), 445–459.
• [2] Pennes H. H., Analysis of tissue and arterial blood temperatures in the resting human forearm, Journal of Applied Physiology, 1, (1948), 93–122.
• [3] Telega J. J., Stańczyk M., Modelling of soft tissues behaviour, Modelling in Biomechanics, Lecture Notes 19, Institute of Fundamental Technological Research, Polish Academy of Science, Warsaw 2005, pp. 191–453.
• [4] Yue K., Zhang X., Yu F., An analytic solution of one-dimensional steady-state Pennes’ bioheat transfer equation in cylindrical coordinates, Journal of Thermal Science, 13, 3, (2004), 255–258.
• [5] Ping Y., Numerical analysis of an equivalent heat transfer coefficient in a porous model for simulating a biological tissue in a hyperthermia therapy, International Journal of Heat and Mass Transfer, 52, (2009), 1734–1740.
• [6] Kruglenko E., Gambin B., Numerical modeling of the heating area and heat sources intensities in rat liver in vivo, due to the concentrated ultrasound beam of low intensity, Proceeding of Conference, The 57th Open Seminar on Acoustics (in Polish), Gliwice 2010, pp. 103–106.
• [7] Wójcik J., Conservation of energy absorption in acoustic fields for linear and nonlinear propagation, The Journal of the Acoustical Society of America, 104, 5, (1998), 2654–2663.
• [8] Kujawska T., Wójcik J., Nowicki A., Temperature field induced in rat liver in vitro by pulsed low intensity focused ultrasound, Hydroacoustics, 13, (2010), 156–162.