Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

• Autorzy: Mudra R. , Muroi C. , Niederer P. , Keller E.
• Języki publikacji: EN

Abstrakty

EN

The cerebral blood flow (CBF) is an important vital parameter in neurointensive care. Currently, there is no non-invasive method for its measurement that can easily be applied at the bedside. A new tool to determine CBF is based on near-infrared spectroscopy (NIRS) applied together with indocyanine green (ICG) dye dilution. From a bilateral measurement on selected regions on the head of infrared (IR) absorption at various wavelengths during the dilution maneuver, the vascular perfusion characteristics of the two brain hemispheres can be determined in terms of mean transit time (mtt) of ICG, cerebral blood volume (CBV) and CBF. So far, on nine healthy volunteers, NIRS ICG dye dilution bihemispheric measurements were performed, which yielded to mtt given as median (range) of 9.3 s (5.1-16.3 s), CBV of 3.5 ml/100 g (1.7-4.1 ml/100 g), and CBF of 18.2 ml/(100 gxmin) [11.1-48.6 ml/(100 g×min)]. Additionally, the blood flow index (BFI) was calculated with BFI= 13.8 mg/(100 gxs) [6.6-15.2 mg/(100 gxs)]. The Spearman rank correlation coefficient between CBF and BFI was R_S = 0.76. However, as the Bland & Altman plot between CBFNIRS and the CBF_BFI documents, the limits of agreement are rather wide (21.9 ± 6.7). Under physiological conditions in healthy volunteers, no differences could be detected between the hemispheres.

Słowa kluczowe

EN

cerebral blood flow; indocyanine green dye; lasers in medicine; near infrared spectroscopy

• Wydawca: Stowarzyszenie Elektryków Polskich ; Polska Akademia Nauk ; Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
• Czasopismo: Opto-Electronics Review
• Rocznik: 2008
• Tom: Vol. 16, No. 3
• Strony: 297--308
• Opis fizyczny: Bibliogr. 47 poz., il., wykr.

Twórcy

autor

Mudra R.

autor

Muroi C.

autor

Niederer P.

autor

Keller E.

• Institute of Biomedical Engineering ETH/UNIZH, Gloriastrasse 35, 8092 Zürich, Switzerland,

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