Advantages of fluorescence over diffuse reflectance measurements tested in phantom experiments with dynamic inflow of ICG

• Autorzy: Milej D. , Kacprzak M. , Żołek N. , Sawosz P. , Gerega A. , Maniewski R. , Liebert A.
• Języki publikacji: EN

Abstrakty

EN

Time-resolved measurements of diffuse reflectance and fluorescence were carried out using phantom with dynamic inflow of indocyanine green (ICG) in tubes located at different depths. Better sensitivity of fluorescence signals related to the inflow of the dye was observed in comparison to simultaneously acquired diffuse reflectance. Obtained results can be referred to results of in-vivo measurements. We have observed much larger amplitude of changes in relative number of detected photons, mean time of flight and variance of the distributions of times of arrival of fluorescence photons than amplitudes of respective parameters measured from diffuse reflectance distributions of times of flight of photons. The constructed phantom allows us to study influence of concentration of the dye in the tube and the surrounding medium as well as temporal relation between appearance of the boli in deeper and superficial tube. Results of the study were used in optimization of the time-resolved multichannel system for simultaneous monitoring of fluorescence and reflectance.

Słowa kluczowe

EN

fluorescence; diffuse reflectance; time-resolved measurements; indocyanine green light propagation in tissues

• Wydawca: Stowarzyszenie Elektryków Polskich ; Polska Akademia Nauk ; Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
• Czasopismo: Opto-Electronics Review
• Rocznik: 2010
• Tom: Vol. 18, No. 2
• Strony: 208--213
• Opis fizyczny: Bibliogr. 23 poz., il., wykr.

Twórcy

autor

Milej D.

autor

Kacprzak M.

autor

Żołek N.

autor

Sawosz P.

autor

Gerega A.

autor

Maniewski R.

autor

Liebert A.

• Institute of Biocybernetics and Biomedical Engineering PAS, 4. Ks. Trojdena Str., 02-109 Warsaw, Poland,

Bibliografia

• [1] F. F. Jobsis: Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198, 1264-1267, 1977.
• [2] A. Villringer and B. Chance: Non-invasive optical spectroscopy and imaging of human brain function. Trends Neurosci. 20, 435-442, 1997.
• [3] H. Obrig, J. Steinbrink and A. Villringer: Near-infrared spectroscopy in stroke: From research to clinical practice - response. Stroke 35, 2430-2431, 2004.
• [4] M. Hope-Ross: Adverse reactions due to indocyanine green. Ophthalmology 101, 529-533, 1994.
• [5] N. de Liguori Carino, D. A. O'Reilly, K. Dajani, P. Ghaneh, G. J. Poston and A. V. Wu: Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure. Eur. J. Surg. Oncol. 35, 957-962, 2009.
• [6] T. Ishizawa, N. Fukushima, J. Shibahara, K. Masuda, S. Tamura and T. Aoki: Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer 115, 2491-504, 2009.
• [7] Q. S. Sheng, R. Lang, Q. He, Y. J. Yang, D. F. Zhao and D. Z. Chen: Indocyanine green clearance test and model for end-stage liver disease score of patients with liver cirrhosis. Hepatob. Pancreat. Dis. 8, 46-49, 2009.
• [8] T. Desmettre, J. M. Devoisselle and S. Mordon: Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography. Surv. Ophthalmol. 45, 15-27, 2000.
• [9] Y. L. He, H. Tanigami, H. Ueyama, T. Mashimo and I. Yoshiya: Measurement of blood volume using indocyanine green measured with pulse-spectrophotometry: its reproducibility and reliability. Crit. Care Med. 26, 1446-1451, 1998.
• [10] H. Ishihara, H. Okawa, T. Iwakawa, N. Umegaki, T. Tsubo and A. Matsuki: Does indocyanine green accurately measure plasma volume early after cardiac surgery? Anesth. Analg. 94, 781-786, 2002. table of contents.
• [11] J. A. Guenette, I. Vogiatzis, S. Zakynthinos, R. Boushel, D. Athanasopoulos, H. Wagner, P. D. Wagner and R. Boushel: Human respiratory muscle blood flow measured by near-infrared spectroscopy and indocyanine green. J. Appl. Physiol. 104, 1202-1210, 2008.
• [12] T. S. Leung, N. Aladangady, C. E. Elwell, D. T. Deply and K. Costeloe: A new method for the measurement of cerebral blood volume and total circulating blood volume using near infrared spatially resolved spectroscopy and indocyanine green: application and validation in neonates. Pediatr. Res. 55, 134-141, 2004.
• [13] C. Terborg, S. Bramer, S. Harscher, M. Simon and O. W. Witte: Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green. J. Neurol. Neurosur. Ps. 75, 38-42, 2004.
• [14] E. Keller, A. Nadler, H. Alkhadi, S. Kollias, Y. Yonekawa and P. Niederer: Noninvasive measurement of regional cerebral blood flow and regional cerebral blood volume by near-infrared spectroscopy and indocyanine green dye dilution. Neuroimage 20, 828-839, 2003.
• [15] J. Steinbrink, S. Boden, H. Obrig, C. Köhncke, H. Benav and S. P. Koch: Relevance of depth resolution for cerebral blood flow monitoring by near-infrared spectroscopic bolus tracking during cardiopulmonary bypass. J. Thorac. Cardiov. Sur. 132, 1172-1178, 2006.
• [16] A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer and H. Rinneberg: Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons. Appl. Optics 43, 3037-3047, 2004.
• [17] A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg and A. Villringer: Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance. Neuroimage 24, 426-435, 2005.
• [18] J. Steinbrink, A. Liebert, H. Wabnitz, R. Macdonald, H. Obrig, A. Wunder, R. Bourayou, T. Betz, J. Klohs, U. Lindauer, U. Dirnagl and A. Villringer: Towards noninvasive molecular fluorescence imaging of the human brain. Life. Sci. R. 5, 296-303, 2008.
• [19] A. Liebert, H. Wabnitz, H. Obrig, R. Erdmann, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer and J. Steinbrink: Non-invasive detection of fluorescence from exogenous chromophores in the adult human brain. Neuroimage 31, 600-608, 2006.
• [20] A. Liebert, H. Wabnitz, N. Zolek and R. Macdonald: Monte Carlo algorithm for efficient simulation of time-resolved fluorescence in layered turbid media. Opt. Express 16, 13188-131202, 2008.
• [21] A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald and H. Rinneberg: Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance. Neuroimage 24, 426-435, 2005.
• [22] M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek and R. Maniewski: Time-resolved optical imager for assessment of cerebral oxygenation. J. Biomed. Opt. 12, 034019, 2007.
• [23] A. Liebert, H. Wabnitz, J. Steinbrink and H. Obrig: Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons. Appl. Optics 43, 3037-3047, 2004.