Izoksazolidynowe analogi nukleozydów

Kokosza, K.; Piotrowska, D. G.

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Tytuł artykułu

Izoksazolidynowe analogi nukleozydów

Autorzy

Kokosza K. , Piotrowska D. G.

Treść / Zawartość

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Warianty tytułu

Isoxazolidine analogues of nucleosides

Języki publikacji

Abstrakty

Compounds having isoxazolidine moiety are of special interest since they show a broad spectrum of biological activity, including anticancer [1–5], antiviral [6], antibacterial [7–9] and antifungal activities [9–12]. Extensive studies on isoxazolidine moiety containing compounds resulted in discovery of several potentially antiviral and anticancer drugs (e.g. pyridemine-A 1 [2, 3], as well as isoxazolidines substituted with thymine and 5-fluorouracil 52a (AdT) [38–40] and 59 [(–)-AdFU] [41–43], respectively). In this review the most spectacular examples of the synthesis of isoxazolidine analogues of nucleosides are discussed and their biological activity is emphasized.

Słowa kluczowe

1,3-dipolarna cykloaddycja nitrony izoksazolidyny analogi nukleozydów nukleozasady C-nukleozydy homonukleozydy nukleozydy fosfonylowane nukleozydy psiko-nukleozydy aktywność przeciwwirusowa aktywność przeciwnowotworowa

1,3-dipolar cycloaddition nitrones isoxazolidines nucleoside analogues nucleobases C-nucleosides homonucleosides nucleosides phosphonylated nucleosides psico-nucleosides antiviral activity anticancer activity

Wydawca

Polskie Towarzystwo Chemiczne

Czasopismo

Wiadomości Chemiczne

Rocznik

2012

Tom

[Z] 66, 11-12

Strony

1041--1070

Opis fizyczny

Bibliogr. 77 poz., schem.

Twórcy

autor

Kokosza K.

autor

Piotrowska D. G.

Zakład Chemii Bioorganicznej, Wydział Farmaceutyczny, Uniwersytet Medyczny w Łodzi, ul. Muszyńskiego 1, 90-151 Łódź, k.kokosza@wp.pl

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