Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część I

• Autorzy: Nawrocka W. P. , Nowicka A. , Liszkiewicz H.

Warianty tytułu

EN

Biological activity of 2-amino -1H-benzimidazole derivatives. Part I

• Języki publikacji: PL

Abstrakty

EN

The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. 2-Aminobenzimidazole occurs in a broad spectrum of drugs and pharmacological agents with anticancer [21], antibacterial [14], antiviral [10], analgesic or antiaggregatory properties. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world. Mebendazole represents a big group of antiparasitic drugs [25]. Antihistaminic II-nd generation drug with selective activity towards H1 receptors represents Astemizol [2]. Antiviral drugs are: Enviroksym and its isomer Zinviroksym and Enviraden [3–5]. Synthesized 2-aminobenzimidazole derivatives are active against HCV [7], HIV [8, 9] or HCHV [11]. Selected compounds exhibit antiviral [3–5], antifungal [22–24] and antiparasitic [26–28] activity. Some of them can be used in the treatment of bacterial infections [12–14]. Many of 2-aminobenzimidazole analogues are histamine H1, H2, H3 and also H4 receptor antagonists [30, 33, 35, 39].

Słowa kluczowe

PL

pochodne 2-aminobenzimidazolu; aktywność biologiczna

EN

2-aminobenzimidazole derivatives; biological activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2012
• Tom: [Z] 66, 9-10
• Strony: 811--838
• Opis fizyczny: Bibliogr. 39 poz., schem.

Twórcy

autor

Nawrocka W. P.

autor

Nowicka A.

autor

Liszkiewicz H.

• Katedra i Zakład Technologii Leków Uniwersytet Medyczny im Piastów Śląskich we Wrocławiu pl. Nankiera 1, 50-140 Wrocław,

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