Chemiczne aspekty celowanej terapii przeciwnowotworowej II. Połączenia nośnik -lek

• Autorzy: Werengowska K. M. , Wiśniewski M. , Terzyk A.P. , Gurtowska N. , Drewa T. A. , Olkowska J.

Warianty tytułu

EN

Chemical aspects of targeted anticancer therapy II . Bond of carrier to drug

• Języki publikacji: PL

Abstrakty

EN

Traditional anticancer therapy is usually low effective. Popular and common drugs applied in anticancer therapy are characterized by low solubility and nonspecific biodistribution in an organism. The chemotherapy kills not only cancer but also healthy cells [4]. Building of modern drug delivery systems based on nanocarriers is a new method of anticancer treatment. The present study is directed towards nanomaterials (as carbon nanotubes, liposomes, polymeric micelles) as modern drug carriers. Thus, we characterized mechanisms of actions of traditional chemotherapeutics: paclitaxel, cisplatin and doxorubicin (Figs. 3–5) [1, 15, 21]. The purpose of this study is a description of the bioconjugation of drug-nanocarrier. Chemotherapeutics can be connected to external or internal surfaces of nanocarriers (Fig. 6) [6]. We described two main methods of drug delivery from internal space of nanocarriers: nanoextraction and nanocondensation (Fig. 7) [32]. The type of drug-carrier bonding can be covalent or noncovalent. We report recent advances in the field showing the formation of esters (Figs. 10–11) [28, 29, 53, 54], acethylhydrazone (Fig. 12) [55–61], amides [62–64], and disulfides groups [12, 65]. These reactions depend on functional groups in structures of drugs and require suitable modification of nanocarrier surfaces. In practice, the functionalization of nanocarrier surface is associated with the covering with polymers including PE G, HPMA, PG and PL GA [3]. Adsorption is the most popular process of bonding chemotherapeutic and nanomaterials (Fig. 13) [66]. Special attention is paid to electrostatic interaction between drugs: paclitaxel [74], cisplatin [59, 76, 77], doxorubicin [67–73] and nanocarriers: carbon nanotubes and/or polymeric micells. By application of modern anticancer therapy, drugs are preserved from lysosomal degradation and to fast reaction in biological environment. Finally, nanocarriers improve adsorption of drug and increase concentration of drug only in cancer tissues [6, 7].

Słowa kluczowe

PL

nanonośniki leków; leki przeciwnowotworowe; wiązania kowalencyjne; adsorpcja

EN

nanocarriers of drugs; anticancer drugs; covalent bonds; adsorption

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2012
• Tom: [Z] 66, 7-8
• Strony: 637--670
• Opis fizyczny: Bibliogr. 83 poz., rys., schem., tab.

Twórcy

autor

Werengowska K. M.

autor

Wiśniewski M.

autor

Terzyk A.P.

autor

Gurtowska N.

autor

Drewa T. A.

autor

Olkowska J.

• Wydział Chemii Uniwersytetu Mikołaja Kopernika w Toruniu, Katedra Chemii Materiałów, Adsorpcji i Katalizy, Zespół Fizykochemii Materiałów Węglowych,,

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