Chemiczne aspekty celowanej terapii przeciwnowotworowej I. Kowalencyjne połączenia ligand-nośnik

• Autorzy: Werengowska K. M. , Wiśniewski M. , Terzyk A.P. , Gurtowska N. , Drewa T. A.

Warianty tytułu

EN

Chemical as pects of targeted anticancer therapy I. Covalent bond of ligand to carier

• Języki publikacji: PL

Abstrakty

EN

In this study we describe the most popular biomedical engineering nanoparticles including carbon nanotubes [17-20], liposomes [4-7], polymeric micells [11-13], quantum dots [3, 21-23], hydrogels [24-27], dendrimers [14-16] which are recently considered as modern drug carriers. These nanomaterials are applied for cancer diagnostic and targeted delivery of active compounds as chemotherapeutics in so called targeted therapy. Thus, we characterized the ideas of targeted therapy for which compositions of carriers with antibody are constructed (Figs. 3, 4). We also compared the traditional and targeted mechanisms [1, 3, 28-29] of drug delivery (Fig. 2). During targeted therapy only the essential dose of drug (less than during conventional chemotherapy) is delivering to the cancer cell. In additional, the application of targeted therapy reduces side effects, being very characteristic for the traditional treatment. The anticancer compound can selectively hits the target only, due to the presence of the ligands attached to the surface of nanocarirer. We characterized ligands which are often use in nanomedicine: antibodies [33-37], folic acid [30-33], peptides [33, 38, 39], aptamers [33, 40, 41] and transferrin [33, 42-44]. The purpose of this study is description of the bioconjugation of ligand-nanocarrier. This step is necessary and very important in synthesis of the novel drug delivery systems in targeted anticancer therapy. We report recent advances in the field showing the formation of amides (Figs. 6-8) [51-57], thioethers (Figs. 9-11) [52, 60-66], disulfides (Fig. 12) [69], and acethyl-hydrazone groups (Fig. 13) [73]. Special attention is paid to the process such as Diels-Alder (Figs. 14, 15) [74, 75] and "click chemistry" through the cycloaddition of Huisgen (Figs. 16, 17) [79-82]. We describe also the reaction of Staudinger [83] and the process of formation Schiff 's base [84]. The processes enable very mild and selective modification of the carriers through formation of amide bound. These methods ware less popular but allow the fictionalization of nanocarriers in biomedical application. Each reaction or process needs special and individual environment and conditions, which are summarized in Table 1.

Słowa kluczowe

PL

nanonośniki leków; terapia celowana; ligandy; wiązania kowalencyjne; system dostarczania leków przeciwnowotworowych

EN

nanocarriers of drugs; targeted therapy; ligands; covalent bond; anticancer drug delivery system

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2011
• Tom: [Z] 65, 9-10
• Strony: 887--915
• Opis fizyczny: Bibliogr. 84 poz., tab., wykr.

Twórcy

autor

Werengowska K. M.

autor

Wiśniewski M.

autor

Terzyk A.P.

autor

Gurtowska N.

autor

Drewa T. A.

• Wydział Chemii Uniwersytetu Mikołaja Kopernika w Toruniu, Katedra Chemii Materiałów, Adsorpcji i Katalizy, Zespół Fizykochemii Materiałów Węglowych ul. Gagarina 7, 87-100 Toruń,

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