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Single-molecule RNA enzymology : using FRET to explore folding and conformational dynamics of ribozymes
Języki publikacji
Abstrakty
Ribozymes are biologically important macromolecules that play a crucial role in cell metabolism and functions. Knowledge of folding and catalytic properties of ribozymes can be useful in biotechnology and medicine. In this work, we present a review of single-molecule RNA enzymology with particular emphasis on folding and catalysis observed with single-molecule FRET. Single-molecule spectroscopy provides insight into behaviors of individual molecules without averaging inherent in bulk measurements. In the first section we introduce ribozymes as RNA enzymes [1, 2]. In the second section, we present the structure of RNA molecules and examples of reaction mechanisms (Fig. 1) and function of different types of ribozymes (Fig. 2–5). Next, we review single-molecule FRET spectroscopy (Fig. 6, 7, Eqs. 1, 2). In the fourth section, we present examples of folding dynamics of ribozymes. In the fifth part, we focus on ribozyme catalysis (Fig. 8, 9). We discuss the coupling of conformational dynamics with catalytic reactions. In the last part we present methods of data analysis that can be used to obtain the kinetic rates from single molecule FRET experiments (Fig. 10).
Wydawca
Czasopismo
Rocznik
Tom
Strony
173--193
Opis fizyczny
bibliogr. 45 poz., schem., wykr.
Twórcy
autor
autor
- Pracownia Dynamiki Procesów Fizykochemicznych, Wydział Chemii, Uniwersytet im. Adama Mickiewicza ul. Grunwaldzka 6, 60-780 Poznań, Marta.Hajdziona@amu.edu.pl
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUS8-0002-0022