Pochodne akrydyny/akrydonu - synteza, aktywność biologiczna i zastosowanie kliniczne

• Autorzy: Dzierzbicka K. , Kawzowicz A. , Koc A. , Kukowska-Kaszuba M.

Warianty tytułu

EN

Acridine/acridone derivatives - synthesis, biological activity and clinical application

• Języki publikacji: PL

Abstrakty

EN

Nowadays the battle with tumor diseases and bacterial infections is an important test for the scientists. Therefore a lot of attention is focused on obtaining novel, more effective, selectively acting and less toxic drugs. Because of that reason, compounds with wide range of action like acridines/acridones are of great interest for scientists. This study contains synthesis and biological activity of acridine/acridone derivatives which are used in medicine as an antitumor agents and those which are at clinical trials. Among the synthetic methods there are modifications of Ullmann synthesis [2, 3, 9]. Lately Belmont et al. [11, 12] described a new methodology for the synthesis of 1,3,7-trisubstituted acridines, 1-amino-acridine and tetrahydro-cyclopenta[c]acridine-2,5-diones (Scheme 5). The starting materials are commercially available quinolines. Among acridine/acridone group there are compounds with diffe-rent molecular targets, e.g. topoisomerase inhibitors [1, 19-33], telomerase inhibitors [1, 34], protein-kinases inhibitors [36-40], P-glycoproteine inhibitors [56, 57, 76], conjugates with metals [1] and hypoxia-selective derivatives [2, 41-55]. This paper also describes compounds useful in Alzheimer disease [5, 16], antibacterial [2, 5], antiparasites [4, 5] and antiviral infections [5, 13, 14].

Słowa kluczowe

PL

pochodne akrydyny/akrydonu; aktywność biologiczna; synteza; zastosowanie kliniczne

EN

acridine/acridone derivatives; biological activity; synthesis; clinical application

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2009
• Tom: [Z] 63, 1-2
• Strony: 107--139
• Opis fizyczny: bibliogr. 78 poz., wykr.

Twórcy

autor

Dzierzbicka K.

autor

Kawzowicz A.

autor

Koc A.

autor

Kukowska-Kaszuba M.

• Katedra Chemii Organicznej, Wydział Chemiczny, Politechnika Gdańska, ul. G. Narutowicza 11/12, 80-952 Gdańsk

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