Insulinonaśladowcze i przeciwcukrzycowe właściwości związków wanadu

• Autorzy: Kupcewicz B. , Budzisz E.

Warianty tytułu

EN

Insulin-mimetic and anti-diabetic properties of vanadium compounds

• Języki publikacji: PL

Abstrakty

EN

Vanadium is a trace element, which may be beneficial for human and developed as clinically useful metallopharmaceutical. Over the last 20 years a wide range of medicinal aspects of various compounds of vanadium have been investigated and documented [10-21]. Vanadium displays relevant biological actions such as insulin-mimicking or spermicidal [5-7] as well as it shows antitumor activity [3, 4]. This review has focused on vanadium inorganic compounds and organic complexes which have insulin-mimetic and anti-diabetic properties. Vanadium-based therapeutic agents belong to the class of compounds in which active is the metal ion and the ligand plays only an ancillary role - delivers active metal to target tissues what may have important implications for the bioavailability and pharmacokinetic properties of vanadium. Vanadium salts such as oxovanadium(IV) sulphate (vanadyl sulphate) VOSO4 or sodium orthovanadate(V) NaVO3 and some vanadium organic complexes are potent insulin-mimetic compounds for treating both type I and type II in animal model, cell culture systems and human diabetes. Many studies have demonstrated that the oral administration of vanadium compounds normalizes blood glucose levels, stimulates glucose intake into cells and causes inhibition of glikoneogenesis and lypolysis. Vanadyl sulphate and other simple salts are effective but unfortunately have poor uptake through gastrointestinal system and have some toxic effects. Complexation with organic ligands may improve vanadium efficacy and decrease toxic side effects. Since 1990 several vanadium compounds (vanadyl, vanadate and peroxovanadate) with organic ligands have been proposed for this purpose. This review describes vanadyl complexes with ligand such as maltol and its derivatives, picolinate ion, flavonoids, sulphur containing compounds and hypoglycemic drugs (metformine and thiazolidenodiones). In recent years some VO(IV) complexes with maltol - bis(maltolato)oxovanadium (BMOV) and ethylmaltol (BEOV) have been proposed for clinical use in humans. BEOV has in 2000 completed I-st phase of human clinical trials. To asses the insulinomimetic and anti-diabetic activities of vanadium(IV) complexes several in vitro- and in vivo systems have been performed. Hypoglycemic and glucose normalizing activity were investigated in vivo in both type I and II diabetic animal (mice and rats) models. In vitro insulinomimetic activity was examined in isolated rat adipocytes. Alternatively for improving bioavailability and anti-diabetic efficacy of vanadium several novel drug delivery systems such as chitosan-hydrogel or enteric-coated capluses containing vanadium [55, 56, 60] compounds have been tested.

Słowa kluczowe

PL

związki wanadu; cukrzyca

EN

vanadium compounds; diabetes

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2009
• Tom: [Z] 63, 1-2
• Strony: 85--106
• Opis fizyczny: bibliogr. 70 poz., wykr.

Twórcy

autor

Kupcewicz B.

autor

Budzisz E.

• Katedra i Zakład Chemii Nieorganicznej i Analitycznej, Wydział Farmaceutyczny Collegium Medicum w Bydgoszczy, UMK w Toruniu ul. Skłodowskiej Curie 9, 85-094 Bydgoszcz

Bibliografia

• [1] D. Rehder, Inorg. Chem. Commun., 2003. 6, 604.
• [2] A.Goc, Central Eur. J. Biol., 2006, 1, 314.
• [3] B. Desotze, Anticancer Rev.. 2004, 24(3a). 1529.
• [4] M.M. Harding, G. Mokdsi, Curr. Med. Chem., 2000, 7. 1289.
• [5] O.J. D'Cruz, F.M. Uckun, Adv. Reprod.. 1998,1, 102.
• [6] O.J. D'Cruz, P. Ghosh, F.M. Uckun, Biol. Reprod., 1998, 58, 1515.
• [7] G.B. Less, N.W. Ockwig, P.G. Rasmussen, Inorg. Chem., 2006, 45, 7105.
• [81 E. Otto-Buczkowska, P. Jarosz-Chobot, K. Tucholski. Pol. J. Endocrin., 2008, 59, 246.
• [9] A. Czech. J. Tatoń, Przew. Lek.. 2004, 4, 63.
• [10] Y. Shechter, I. Goldwaser. M. Mironchik, M. Fridkin, D. Getel, Coord. Chem. Rev., 2003. 237, 3.
• [11] H. Sakurai, Biomed. Res. Trace Elements, 2007, 18, 241.
• [12] D.C. Crans, J.J. Smee, E. Gaidamauskas, L. Yang. Chem. Rev., 2004,104, 849.
• [13] S. Garcia-Vincente, F. Yraola, L. Marti, E. Gonzalez-Munoz, M..I. Garcia-Barrado, C. Canto, A. Abella, S. Bour, R. Artuch, C. Sierra, N. Brandi, C. Carpene, J. Moratinos, M. Camps, M. Palacin, X. Testar, A. Guma. F, Albericio. M. Royo. A. Mian. A. Zorzano, Diabetes, 2007, 56, 486.
• [14] K. Kawabe. Y. Yoshikawa, Y. Adachi, H. Sakurai, Life Sci., 2006, 78, 2860.
• [15] M. Hiromura, H. Sakurai, Chem. Biodiversity, 2008, 5, 1615.
• [16] D.A. Roess, S.M.L. Smith, P. Winter, J. Zhou, P. Dou, B. Baruah, A.M. Trujillo. N.E. Levinger. X. Yang, B.G. Barisas, D.C. Crans. Chem. Biodiversity, 2008, 5, 1558.
• [17] E.J. Baran. J. Inorg. Biochem., 2000, 80, 1.
• [18] D.C. Crans, M. Mahroof-Tahir, M.D. Johnson, P.C. Wilkins, L. Yang, K. Robbins, A. Johnson, J.A. Alfano, M.E. Godzala. L.T. Austin, G.R. Willsky. Inorg. Chim. Acta, 2003, 356. 365.
• [19] A. Boduła, M. Wdowczyk, R. Adamiec, Postępy Hig. Med. Dosw. (online). 2005, 59, 203.
• [20] K.G. Peters. M.G. Davis, B.W. Howard. M. Pokross, V. Rastogi. C. Diven, K.D. Greis K.D, E. Eby-Wilkens. M. Maier, A. Evdokimov, S. Soper, F. GenbaufTe, J. Inorg. Biocbem., 2003, 96, 321.
• [21] A.B. Goldfine, M.E. Patti, L. Zuberi, B.J. Goldstein, R. LeBlanc, EJ. Landaker, Z.Y. Jiang. G.R. Willsky. C.R. Kahn, Metabolism, 2000, 49, 400.
• [22] M.Z. Mehdi. S.K. Pandey, J.F. Theberge. A.K. Srivastava, Cell. Biochem. Biophys., 2006, 44. 73.
• [23] I. Goldwaser, D. Gefel, E. Gershonov, M. Fridkin, Y. Shechter. J. Inorg. Biochem.. 2000.80. 21.
• [24] M.C. Cam, R.W. Brownsey, J.H. McNeill, Can. J. Physiol. Pharmacol. 2000,78. 829.
• [25] A.K. Srivastava, M.Z. Mehdi, Diabetic Mod.. 2005, 22, 2.
• [26] T. Kiss. T. Jakusch, D. Hollender, A. Dornyei. E.A. Enyedy, J.C. Pessoa, H. Sakurai. Sanz-Medel, Coord. Chem. Rev., 2007.
• [27] D.C. Crans, J. Inorg. Biochem.. 2000, 80, 123.
• [28] K.H. Thompson, C. Orvig, Coord. Chem. Rev., 200I, 219-221. 1033.
• [29] K.G. Peters, M.G. Davis, B.W. Howard, M. Pokross, V. Rastogi, C. Diven. K.D. Greis, E. Eby--Wilkens, M. Maier, A. Evdokimov, S. Soper, F. Genbauffe, J. Inorg. Biochem., 2003, 96. 321.
• [30] K.H. Thompson, J. Chiles, V.G. Yuen, J. Tse, J.H. McNeill, C. Orvig, J. Inorg. Biochem., 2004, 98, 683.
• [31] H. Yasui, A. Tamura, T. Takino, H. Sakurai, J. Inorg. Biochem.. 2001, 91, 327.
• [32] K.H. Thompson, B.D. Liboiron, Y. Sun, K.D.D. Bellman, I. A. Setyawati, B.O. Patrick, V. Karunaratne, G. Rawji, J. Wheeler, K. Sutton, S. Bhanot, C. Cassidy, J.H. McNeill. V.G. Yuen, C. Orwig, J. Biol. Inorg. Chem., 2003, 8, 66.
• [33] K.H. Thompson, B.D. Liboiron, Y. Sun, K.D.D. Bellman. I.A. Setyawati, B.O. Patrick, V. Karunaratne, G. Rawji, J. Wheeler, K. Sutton. S. Bhanot, C. Cassidy, J.H. McNeill, V.G. Yuen, C.J. Orvig, Biol. Inorg. Chem., 2003, 8, 66.
• [34] K.H. Thompson, C. Orvig. J. Inorg. Biochem.. 2006, 100. 1925.
• [35] T. Takino. H. Yasui, A. Yoshitake, Y. Hamajima, R. Matsuahita, J. Takada, II. Sakurai, J. Biol. Inorg. Chem.. 2001,6, 133.
• [36] A. Saeed, A.I. Anvarhusein. A. Saqib, A.R. Al-Arfaj, Polyhedron, 2006, 25, 1633.
• [37] R.C. Maurya, S. Rajput, J. Mol. Struct., 2007, 833, 133.
• [38] Y. Zhang, X. Yang, K. Wang, D.C. Crans, J. Inorg. Biochem., 2006, 100, 80.
• [39] A. Sheela, S.M. Roopan, R. Vijayaraghavan, Eur. J. Med. Chem., 2008, 43, 2206.
• [40] K.C. Ong, H.E. Khoo, Life Sci.. 2000, 67, 1695.
• [41 ] L.H. Cazarolli, L. Zanatta. A.P. Jorge, E. Sousa, H. Horst, V.M. Woehl, M.G. Pizzolatti, B. Szpoganicz, F.R.M.B. Silva, Chemico-Biological Interactions, 2006. 163, 177.
• [42] X. Mingjin, X. Guangjun, L. Ling, L. Weiping, N. Yanfen, Y. Sniping, Eur. J. Med. Chem., 2007, 42, 817.
• [43] N. Durai, G. Saminathan, J. Clin. Biochem. Nutr., 1997, 22, 31.
• [44] M. Xie, G. Xu, L. Li, W. Liu, Y. Niu, S.Yan, Eur. J. Med. Chem., 2007, 42, 817.
• [45] H. Sakurai, Y. Kojima, Y. Yoshikawa, K. Kawabe, H. Yasui. Coord. Chem. Rev.. 2002, 226. 187.
• [46] H. Sakurai, H. Sano, T. Takino, H. Yasui, J. Inorg. Biochem., 2000, 80, 99
• [47] D. Render, J.C. Pessoa, C.F.G.C. Geraldes, M.M.C.A. Castro, T. Kabanos, T. Kiss, B. Meier, G. Micera. L. Pettersson, M. Rangel, A. Salifoglou, I. Turel, D. Wang, J. Biol. Inorg. Chem., 2002, 7, 384.
• [48] H. Sakurai, T.Inohara, Y. Adachi, K. Kawabe, H. Yasui, J. Takada, Bioorg. Med. Chem. Lett., 2004, 14. 1093.
• [49] T. K. Saha, Y. Yoshikawa, H. Yasui, H. Sakurai, Bull. Chem. Soc. Jpn., 2006, 79, 1191.
• [50] W. Basuki, M. Hiromura, H. Sakurai. Bull. Chem. Soc. Jpn.. 2007, 80. 1605.
• [511 P. Noblia, Marisol Vieites, M.H. Torre, A.J. Costa-Filho. II. Cerecetto, M. Gonzalez, M.L. Lavaggi, Y. Adachi. H. Sakurai, D. Gambino, J. Inorg. Biochem., 2006. 100. 281.
• [52] R. Mukherjee, E.G. Donnay, M.A. Radomski. C. Miller, D.A. Redtem. A. Gericke. D.S. Damron, N.E. Brasch, Chem. Coram., 2008, 3783.
• [53] L.C.Y. Woo, V.G. Yuen, K.H. Thompson, J.H. McNeill, C. Orvig, J. Inorg. Biochem., 1999. 76, 251.
• [54] T. Storr, D. Mitchell, P. Buglyo, K.H. Thompson, V.G. Yuen. J.H. McNeill, C. Orvig, Bioconjugate Chem.. 2003. 14.212.
• [55] J. Fugono, H. Yasui, H. Sakurai, J. Pharm. Phannacol., 2002. 54, 611.
• [56] H. Sakurai, J. Fugono, H. Yasui, Mini Rev. Chem. Med., 2004, 4, 41.
• [571 S. Karmaker, T.K. Saha, Y. Yoshikawa, H. Yasui, H. Sakurai. J. Inorg. Biochem., 2006,100, 1535.
• [58] I. Goldwaser, J. Li, E. Gershonov, M. Armoni, F,. Karnieli, M. Fridkin, Y. Shechter, J. Biol. Chem., 1999,274,26617.
• [59] A.L. Edel, M. Kopilas, T.A. Clark, F. Aguilar. P.K. Ganguly. C.E. Heyliger, G.N. Pierce, Metab. Clin. Exp.. 2006, 55, 263.
• [60] K. Koftiji, C.J. Qian, Y. Murata, S. Kawashima, J. Inorg. Biochem., 2005, 99. 1329.
• [61] J.L. Domingo, Biol. Trace Elem. Res. 2002, 88, 97.
• [62] A.K. Srivastava, Mol. Cell. Biochem.. 2000, 206, 177.
• [63] K.M. Wasana. V. Risovica. V.G. Yuen, J.H. McNeill, J. Trace Elem. Med. Biol.. 2006, 19, 251.
• [64] J. Wang, V.G. Yuen, J.H. McNeill, Metabolism, 2001. 50. 667.
• [65] S.M. Brichard, C.J. Bailey, J.C. Henquin, Diabetes. 1990, 39. 1326.
• [66] Y. Adachi, H. Sakurai. Chem. Pharm. Bull. (Tokyo), 2004, 52, 428. (Abstract)
• [67] R. Shukla, R.R. Bhonde, Biometals, 2008, 21, 205.
• [68] W. Basuki, M. Hiromura, Y. Adachi, K. Tayama, M. Hattori, H.Sakurai, Biochem. Biophys. Res. Commun., 2006, 349, 1163.
• [69] H. Yasui. A. Tamura, T. Takino, H. Sakurai. J. Inorg. Biochem., 2002, 91, 327.
• [70] S. Wild, G. Roglic, A. Green. R. Sicree. H. King, Diabetes Care. 2004, 27, 1047.