Makrocykliczne kompleksy radionuklidów w medycynie nuklearnej

Majkowska, A.; Bilewicz, A.

Artykuł - szczegóły

Tytuł artykułu

Makrocykliczne kompleksy radionuklidów w medycynie nuklearnej

Autorzy

Majkowska A. , Bilewicz A.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

Warianty tytułu

Macrocyclic complexes of radionuclides in nuclear medicine

Języki publikacji

Abstrakty

The use of radiometal-labeled small complexes and biomolecules as diagnostic and therapeutic agents is a relatively new area of medical research. Radiopharmaceuticals are radiolabeled molecules designed to deliver ionizing radiation doses to specific disease sites. Between the targeting biomolecule and a radionuclide a bifunctional ligand is inserted, one end of which is covalently attached to the targeting molecule either directly or through a linker whereas the other strongly coordinates a metallic radionuclide. Selection of a bifunctional ligand is largely determined by the nature and oxidation state of a metal ion. The metal chelate can significantly affect the tumor uptake and biodistribution of radiopharmaceuticals based on small biomolecules. This is because in many cases the metal chelate contributes greatly to the overall size and lipophilicity of the radiopharmaceutical. Therefore, the design and selection of the ligand is very important for the development of a clinically useful therapeutic agent. The requirement for high thermodynamic and kinetic stability of the metal complex is often achieved through the use of macrocyclic ligands with a functionalized arm for covalent bonding to the biomolecule. In this review synthesis of bifunctional macrocyclic ligands and properties of radionuclide macrocyclic complexes used in nuclear medicine are presented. We describe results in two areas: substituted macrocyclic aza ligands for chelation of hard metal cations, and macrocycles containing sulphur for complexation of soft metal cations. Special attention was paid to stability of the complexes as well as to their lipophilicity, which affect biological properties of the formed radiopharmaceuticals. We also include a forecast of the near-term opportunities that are likely to determine practice in the next few years.

Słowa kluczowe

medycyna nuklearna radiofarmacja ligandy makrocykliczne

nuclear medicine radiopharmacy macrocyclic ligands

Wydawca

Polskie Towarzystwo Chemiczne

Czasopismo

Wiadomości Chemiczne

Rocznik

2008

Tom

[Z] 62, 7-8

Strony

609--633

Opis fizyczny

bibliogr. 87 poz., tab., wykr.

Twórcy

autor

Majkowska A.

autor

Bilewicz A.

Zakład Radiochemii, Instytut Chemii I Techniki Jądrowej, Ul. Dorodna 16, 03-195 Warszawa

Bibliografia

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Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-article-BUS5-0011-0024