Procedury jednoczesnego testowania wielu hipotez i ich zastosowania w analizie mikromacierzy DNA

• Autorzy: Dudziński M. , Furmańczyk K.

Warianty tytułu

EN

Simultaneous testing procedures of many null hypotheses and their applications in the DNA microarrays analysis

• Języki publikacji: PL

Abstrakty

PL

W naszej pracy rozważamy różne podejścia do problematyki jednoczesnego testowania wielu hipotez zerowych. W tym kontekście omawiamy procedury testowania typu single-step, step-down i step-up. W szczególności, przedstawiamy własności i zastosowania takich miar błędów testowania, jak: FWER, k-FWER, FDP, FDR, pFDR. Wspomniane procedury testowania są intensywnie wykorzystywane w analizie mikromacierzy DNA, która to analiza umożliwia monitorowanie poziomów ekspresji wielu genów jednocześnie oraz znajduje ostatnio szerokie zastosowania w diagnostyce, leczeniu i badaniach medycznych.

EN

In our paper, we consider different approaches to the problem of simultaneous testing of many null hypotheses. In this context, we discuss the single-step, the step-down and the step-up procedures of multiple testing. In particular, we are concerned with their properties and applications in the control of the error rates, such as: FWER, k-FWER, FDP, FDR, pFDR. The mentioned procedures are intensively used in the DNA microarrays analysis, which enables the monitoring of expression levels of many genes simultaneously and is widely applied in recent medical diagnostics, treatment and research.

Słowa kluczowe

PL

procedury jednoczesnego testowania wielu hipotez; FWER; FDP; FDR; p-wartość; q-wartość; mikromacierze DNA

EN

multiple hypothesis testing procedures; familywise error rate; false discovery proportion; false discovery rate; p-values; q-values; DNA microarrays

• Wydawca: Polskie Towarzystwo Matematyczne
• Czasopismo: Matematyka Stosowana : matematyka dla społeczeństwa
• Rocznik: 2007
• Tom: Nr 8
• Strony: 84--108
• Opis fizyczny: bibliogr. 32 poz.

Twórcy

autor

Dudziński M.

autor

Furmańczyk K.

• Konrad Furmańczyk Katedra Zastosowań Matematyki SGGW ul. Nowoursynowska 166 02-787 Warszawa, Poland,

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