Badania polimorfizmu związków bioorganicznych metodami spektroskopii NMR w fazie stałej

• Autorzy: Kaźmierski S. , Potrzebowski M.J.

Warianty tytułu

EN

Solid-state NMR spectroscopy as a tool for searching of polymorphism of the bioorganic derivatives

• Języki publikacji: PL

Abstrakty

EN

Polymorphism is one of the most important and amazing phenomenon in structural chemistry. The knowledge of this phenomenon is crucial both in experimental sciences (e.g.: chemistry, physics and crystallography) and in industry - especially in pharmaceutical industry. It is well known, that polymorphic forms of therapeutic compounds differ in their bioavailability - e.g. the rate of dissolution and equilibrium solubility. In extreme cases, one polymorph may be a medicine whilst the second may be very dangerous or even poisonous. In this light, the possibility to distinguish the desirable form of compound from the useless form, seems to be very important. In our article, some problems concerning the investigation of polymorphism phenomenon by applications of solid-state NMR are presented. The possibilities of current NMR techniques in searching of polymorphism as well as the practical aspects and applications are presented and discussed.

Słowa kluczowe

PL

NMR w fazie stałej; polimorfizm; N-benzoilofenyloalanina; kwercetyna; hydraty ATP

EN

solid state NMR; polymorphism; N-benzoylphenylalanine; quercetin; ATP hydrates

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2006
• Tom: [Z] 60, 11-12
• Strony: 723--745
• Opis fizyczny: tab., wykr., bibliogr. 16 poz.

Twórcy

autor

Kaźmierski S.

autor

Potrzebowski M.J.

• Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk ul. Sienkiewicza 112 90-363 Łódź,

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