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Peptydowe koniugaty antrachinonów i ich aktywność biologiczna

Identyfikatory
Warianty tytułu
EN
Peptidyl anthraquinone conjugates and its biological activity
Języki publikacji
PL
Abstrakty
EN
This article concerns methods of synthesis and biological activity of peptidyl anthraquinones. The group of these components have a big influence on a present medicine. Among components, that were presented in this paper, many number of them show antine-oplastic activity. These peptidyl anthraquinones demonstrate special mechanism of action, stabilizing cleavable complex consisting of topoisomerase, convalently attached to DNA and stop correct replication and transcription. Using of topoisomerases inhibitors in therapy of cancer have promising results. Anthraquinones analogues with peptidyl chain including KCR motif very important in AP-1 protein binding to DNA. This group of compounds can be used as potential transcription factor inhibitors, because they show DNA intercalative binding and recognize specific sequences of DNA binding domains. Synthetic GnRH analogues including rings of anthraquinone present interesting drugs using in reproductive diseases, for instance prostate, ovarian and breast cancer. The mechanism of action of GnRH analogues count on binding to GnRH receptors, which we can find in cells of reproductive organs. MMP-9 activity can be exploited to activate prodrugs and be a target the tumour cells in BM. Cleavage of the prodrugs with MMP-9 resulsts in the liberation of the active form of drug which can be an inhibitor of topoisomerase. Tripeptide derivatives of anthraquinone show the activity as histochemical reagents for detection of TTP I activity. Peptidyl anthraquinones can be also used for protein purification and labeled peptides as biochemical probes for DNA detection.
Rocznik
Strony
523--545
Opis fizyczny
tab., wykr., bibliogr.54 poz.
Twórcy
autor
  • Zakład Chemii Polipeptydów, Wydział Chemii, Uniwersytet Gdański, ul. J. Sobieskiego 18/19, 80-952 Gdańsk
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUS2-0010-0021
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