Inhibitory mikrotubul w terapii przeciwnowotworowej

Dzierzbicka, K.; Kołodziejczyk, A.M.

Artykuł - szczegóły

Tytuł artykułu

Inhibitory mikrotubul w terapii przeciwnowotworowej

Autorzy

Dzierzbicka K. , Kołodziejczyk A.M.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

Warianty tytułu

Inhibitors of microtubule in cancer therapy

Języki publikacji

Abstrakty

Microtubule targeting drugs being in the late preclinical or early clinical development are described in this article. New semisynthetic paclitaxel analogues, natural compounds of diverse structure such as epothilones, combretastatins, colchino-ids or dolastatins and synthetic compounds of low molecular weight such as heterocombretastatins, sulfonamides, phenstatins, indoles and quinolones belong to this category of anticancer medicines. Microtubules are hollow tubes consisting of L- and B-tubulin heterodimer proteins that polymerize parallelly to a cylindrical axis. The targeting of microtubules is an important mechanism in cancer chemotherapy for such drugs as the vinca alkaloids (vincristine (1), vin-blastine (la)), podophilotoxin, their semisynthetic analogues and taxanes (paclitaxel (2), docetaxel (3)) known of their great usefulness in the anticancer therapy. These agents may stabilize microtubules, as the taxanes do, or destabilize them, as it is in the case of the vinca alkaloids. Today, more than 30 compounds targeting tubulin, either stabilizing or destabilizing microtubule dynamics, are in late preclinical or early clinical development. Despite of more than 30 years after the discovery of paclitaxel microtubule inhibitors they are still of the topic of interest of all over the world. In the end of 1990 and up to 2005 year survey articles on the microtubule inhibitors were published .We expect now that the paper which presents last results study may be useful.

Słowa kluczowe

inhibitory mikrotubul tubulina taksol kombretastatyna aktywność przeciwnowotworowa aktywność antymitotyczna

inhibitors of microtubule tubulin taxol combretastatin antitumor activity antimitotic activity

Wydawca

Polskie Towarzystwo Chemiczne

Czasopismo

Wiadomości Chemiczne

Rocznik

2006

Tom

[Z] 60, 5-6

Strony

345--364

Opis fizyczny

wykr., bibliogr. 93 poz.

Twórcy

autor

Dzierzbicka K.

autor

Kołodziejczyk A.M.

Katedra Chemii Organicznej, Wydział Chemiczny, Politechnika Gdańska, ul. G.Narutowicza 11/12, 80-952 Gdańsk

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