Narzędzia chemii kombinatorycznej : nośniki stosowane w syntezie organicznej związków nisko- i wysokocząsteczkowych

Łaźny, R.; Nodzewska, A.

Artykuł - szczegóły

Tytuł artykułu

Narzędzia chemii kombinatorycznej : nośniki stosowane w syntezie organicznej związków nisko- i wysokocząsteczkowych

Autorzy

Łaźny R. , Nodzewska A.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

Warianty tytułu

Tools for combinatorial chemistry: supports used for organic synthesis of small molecules and macromolecules

Języki publikacji

Abstrakty

Progress in combinatorial chemistry is largely determined by development of specific synthetic organic chemistry tools such as solid supports, linkers, polymer supported reactions and methods of analysis, screening and deconvolution of combinatorial libraries. This review article presents basic terms related to polymer supported synthesis, enumerates major advantages of supported reactions, and gives a comprehensive, up to date, overview of support matrices used for immobilization of small and large molecules. The review covers the literature up to September 2002. The supports reviewed include (i) polymeric gels (Merrifield gel, TentaGel, ArgoGelTM, JandaJelTM, PEGA, PEG-PS, PEG-POP, SPOCC, PS-TTEGDA, CLEAR, DendroGel, Pepsyn, and Sucholeiki paramagnetic gel), (ii) soluble polymers (LPS, PEG, ROMP-polymer, PAMAM-dendrymer, Boltron), (iii) macroporous supports (CPG, Pepsyn K, PolyHIPE, ArgoPoreTM) and other developments including SMART reactors, MicroTubeTM, membranes, pins, and cellulose. For most of the supports reviewed basic characteristics such as swelling in different solvents, solvent usability, typical loading, typical anchoring groups, preparation, and recent applications are given or cited. The reviewed literature suggests that the supports most often used for synthesis of small molecules and peptides are based on gel matrices. The variety of available supports, many of which were introduced in the last years, shows that this area of synthetic methodology may grow dynamically in the future.

Słowa kluczowe

chemia kombinatoryczna nośnik polimeryczny synteza na nośniku

combinatorial chemistry polymer supported organic synthesis

Wydawca

Polskie Towarzystwo Chemiczne

Czasopismo

Wiadomości Chemiczne

Rocznik

2003

Tom

[Z] 57, 7-8

Strony

587--625

Opis fizyczny

Bibliogr. 72 poz., schem., tab., wykr.

Twórcy

autor

Łaźny R.

Uniwersytet w Białymstoku, Instytut Chemii, Al. Piłsudskiego 11/4, 15-443 Białystok

autor

Nodzewska A.

Uniwersytet w Białymstoku, Instytut Chemii, Al. Piłsudskiego 11/4, 15-443 Białystok

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Uwagi

Opracowane ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-article-BUS2-0001-0077