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Tytuł artykułu

Neurotoksyczność amyloidalnego β-petydu Alzheimera, rola Met35 i miedzi kompleksowanej przez peptyd

Identyfikatory
Warianty tytułu
EN
Neurotoxicity of the Alzheimer amyloid β-peptide, function of Met35 and copper complexed by the peptide
Języki publikacji
PL
Abstrakty
EN
This short review gives an overview over the oxidation mechanism of methionine (Met) relevant for processes which may lead to the oxidation of amyloid β-peptide (βAP) involved in the pathogenesis of the Alzheimer disease. The βAP-structure dependent CuII-catalyzed oxidation of C-terminal Met35 seems to be the key to the known propensities of this peptide to form reactive oxygen species and free radicals.
Rocznik
Strony
459--475
Opis fizyczny
Bibliogr. 181 poz.
Twórcy
autor
  • Instytut Chemii i Techniki Jądrowej, ul. Dorodna 16, 03-195 Warszawa
autor
  • Instytut Chemii i Ochrony Środowiska, Wyższa Szkoła Pedagogiczna, ul. Armii Krajowej 13/15, 42-200 Częstochowa
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Uwagi
PL
Opracowane ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).
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bwmeta1.element.baztech-article-BUS2-0001-0072
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