Inhibitory integrazy HIV

Niedbała, H.; Polański, J.; Gieleciak, R.

Artykuł - szczegóły

Tytuł artykułu

Inhibitory integrazy HIV

Autorzy

Niedbała H. , Polański J. , Gieleciak R.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

Warianty tytułu

Inhibitors of HIV integrase

Języki publikacji

Abstrakty

AZT was a first anti-HIV drug found during screening performed by National Institute of Health (Bethesda, USA). Anti-HIV drugs or potential drugs grouped according to the molecular target or compound class can be found in the NIH database at [http://www.niaid.nih.gov/daids/dtpdb/intro.htm]. HIV integrase is one of the potential targets of anti-HIV drugs. Integrase is an enzyme that catalyzes the insertion of retrotranscribed viral DNA into the cellular host genome. Its structure is known but until now there is no certified drug targeted at this enzyme. In the 90' several integrase inhibitors were described. The investigations of these compounds allowed finding new active compounds, e.g., styrylchinolines that was described in recent years. In particular, the current publication discusses structure-activity relationships (SAR) for these compounds. It appeared that the SAR data from ex-vivo experiments can be both visualized and interpreted by the use of the Kohonen maps of the electrostatic potetntial of the molecular surface as shown in Figure 2. Finally, the results of the Merck investigations on HIV-1 integrase inhibitors have been briefly discussed.

Słowa kluczowe

inhibitor integraza (IN) enzym wirus HIV farmakoterapia

inhibitor enzyme HIV integrase anti HIV drug

Wydawca

Polskie Towarzystwo Chemiczne

Czasopismo

Wiadomości Chemiczne

Rocznik

2003

Tom

[Z] 57, 3-4

Strony

289--303

Opis fizyczny

Bibliogr. 40 poz., schem.

Twórcy

autor

Niedbała H.

Zakład Chemii Organicznej, Instytut Chemii, Uniwersytet Śląski, ul. Szkolna 9, 40-006 Katowice

autor

Polański J.

Zakład Chemii Organicznej, Instytut Chemii, Uniwersytet Śląski, ul. Szkolna 9, 40-006 Katowice

autor

Gieleciak R.

Zakład Chemii Organicznej, Instytut Chemii, Uniwersytet Śląski, ul. Szkolna 9, 40-006 Katowice

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Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-article-BUS2-0001-0065