Poszukiwanie nowych selektywnych antagonistów receptorów α1 adrenergicznych

• Autorzy: Malawska B. , Kulig K.

Warianty tytułu

EN

Developments in α1 adrenergic recptor antagonists

• Języki publikacji: PL

Abstrakty

EN

α₁,-Adrenergic receptors (α₁-AR) are members of the superfamily of G protein coupled receptors that transduce signals across the cell membrane. α₁-ARs are comprised of multiple subtypes that have been identified by both pharmacological and binding studies [1], To date, they are classified into α_1A, α_1B, and α_1D and the corresponding cloned counterparts termed α_1a, α_1b, and α_1dAR, respectively. These subtypes have different tissue distributions with the α_1A receptors predominating in lower urinary tract tissue, whereas this receptor subtype is less prevalent in the vasculature [2-4]. In recent years, the search for new selective α₁-AR antagonists has intensified, due to their importance in the treatment of hypertension and of benign prostatic hyperplasia (BPH) [5-7]. Tamsulosin, the first α_1A-AR „selective” antagonists for the treatment of BPH, was approved in 1997 [9, 12], A number of α_1A subtype selective antagonists representing different structural classes of compounds were disclosed recently. These include: quinazolines [8-13], phenylalkylamines [9, 12, 14], piperidines [9, 15-23], arylpiperazines [24-36] and related compounds [37, 38], A review on the development of α₁, selective antagonists are presented.

Słowa kluczowe

PL

receptor adrenergiczny; AR; antagoniści receptorów alfa-AR; pochodne chinazoliny; pochodne fenyloalkiloamin; pochodne piperydyny; pochodne arylopiperazyn; lecznictwo; farmaceutyk

EN

adrenergic receptor; AR; alpha-AR receptor antagonists; quinazoline derivatives; phenylalkylamine derivatives; piperidine derivatives; arylpiperazine derivatives; healing; pharmaceutical

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2003
• Tom: [Z] 57, 3-4
• Strony: 267--288
• Opis fizyczny: Bibliogr. 38 poz.

Twórcy

autor

Malawska B.

• Katedra Chemii Farmaceutycznej Collegium Medicum Uniwersytetu Jagiellońskiego, 30-688 Kraków, ul. Medyczna 9

autor

Kulig K.

• Katedra Chemii Farmaceutycznej Collegium Medicum Uniwersytetu Jagiellońskiego, 30-688 Kraków, ul. Medyczna 9

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