Radiochemia w medycynie nuklearnej : radiofarmaceutyki

• Autorzy: Samochocka Krystyna

Warianty tytułu

EN

Radiochemistry in nuclear medicine : radiopharmaceuticals

• Języki publikacji: PL

Abstrakty

EN

Radionuclides and radiopharmaceuticals play the key role in nuclear medicine, both in diagnostics and therapy. Incorporation of radionuclides into biomolecules, and syntheses of radiolabelled compounds of light biological selectivity are a task for radiochemists working in the multidisciplinary field of radiopharmaceutical chemistry. The most commonly used radionuclide, 99mTc, owes this popularity to its both nearly ideal nuclear properties in respect to medical imaging, and availability from inexpensive radionuclide generators. Also numerous other radionuclides are widely used for medical imaging and therapy. Labelling of biomolecules with radioiodine and various positron emitters is getting increasingly important. This review describes some chemical and radiochemical problems we meet while synthesizing and using 99mTc-radiopharmaceuticals and radioiodine-labelled biomolecules. Also represented are the recent developments in the design and use of the second generation radiopharmaceuticals based on bifunctional radiochelates. Several principal routes of fast chemical synthesis concerning incorporation of short-lived positron emitters into biomolecules are outlined as well. The search for chemical structures of high biological selectivity, witch would be activated by slow neutrons, is related to the method of Neutron Capture Therapy, an interesting option in nuclear medicine.

Słowa kluczowe

PL

radiochemia; medycyna nuklearna; radiofarmaceutyki; radiometale; radionuklidy

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 1999
• Tom: [Z] 53, 9-10
• Strony: 661--699
• Opis fizyczny: Bibliogr. 77 poz., tab., wykr.

Twórcy

autor

Samochocka Krystyna

• Wydział Chemii Uniwersytetu Warszawskiego, ul. Żwirki i Wigury 101, 02-089 Warszawa

• Wydział Chemii Uniwersytetu Warszawskiego, ul. Żwirki i Wigury 101, 02-089 Warszawa

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