Long - tail feature of DNA words over - and under -representation in coding sequences

• Autorzy: Nowicka A. , Dudek M. R. , Cebrat S. , Kowalczuk M. , Mackiewicz P. , Dudkiewicz M. , Szczepanik D.
• Języki publikacji: EN

Abstrakty

EN

We have analyzed DNA sequences of known genes from 16 yeast chromosomes (Saccharomyces cerevisiae) in terms of oligonucleotides. We have noticed that the relative abundances of oligonucleotide usage in the genome follow a long-tail Lévy-like distribution. We have observed that long genes often use strongly over-represented and under-represented nucleotides, whereas it was not the case for the short genes (shorter than 300 nucleotides) under consideration. If selection on the extremely over-represented/under-represented oligonucleotides was strong, long genes would be more affected by spontaneous mutations than short ones.

• Wydawca: Institute of Bioorganic Chemistry Scientific Publishers OWN, Polish Academy of Sciences
• Czasopismo: Computational Methods in Science and Technology
• Rocznik: 2000
• Tom: Vol. 6
• Strony: 65--71
• Opis fizyczny: Bibliogr. 28 poz., rys.

Twórcy

autor

Nowicka A.

autor

Dudek M. R.

autor

Cebrat S.

autor

Kowalczuk M.

autor

Mackiewicz P.

autor

Dudkiewicz M.

autor

Szczepanik D.

• Institute of Microbiology, University of Wrocław ul. Przybyszewskiego 63/77, 54-148 Wrocław, Poland