Dose sensitivity enhancement on polymer gel with suspended gold particles

• Autorzy: Afonso L. C. , Schöfer F. , Hoeschen Ch. , Caldas L. V. E.
• Konferencja: Proceedings of the International Conference on Development and Applications of Nuclear Technologies NUTECH-2011, 11-14 September 2011, Kraków, Poland
• Języki publikacji: EN

Abstrakty

EN

The presence of high Z material adjacent to soft tissue, when submitted to irradiation, enhances locally the absorbed dose in these soft tissues. Such an effect occurs due to the outscattering of photoelectrons from the high Z material. Polymer gel (PG) dosimeters were used to investigate this effect. Analytic calculations to estimate the dose enhancement were performed. Samples containing a polymer gel with 0.005 gAu/gPG and a pure polymer gel were irradiated using an X-ray beam produced by 150 kV, filtered with 4 mm Al and 5 mm Cu, which resulted in an approximately 20% greater absorbed dose in the samples with gold in comparison to those with the pure polymer gel. The analytic calculations resulted in a dose enhancement factor of approximately 30% for the gold concentration of 0.005 gAu/gPG.

Słowa kluczowe

EN

polymer gel; dose enhancement; radiation therapy; X-rays

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2012
• Tom: Vol. 57, No. 4
• Strony: 467--472
• Opis fizyczny: BIbliogr. 12 poz., rys.

Twórcy

autor

Afonso L. C.

autor

Schöfer F.

autor

Hoeschen Ch.

autor

Caldas L. V. E.

• Helmholtz Center Munich, German Research Center for Environmental Health, 1 Ingolstädter Ave., D-85764 Neuherberg, Germany and Nuclear and Energy Research Institute (IPEN/CNEN), Săo Paulo, Brazil, Tel.: [phone], Fax: [phone],

Bibliografia

• 1. Berg A (2009) Magnetic-resonance-imaging based polymer gel dosimetry: methodology, spatial resolution, applications. In: Dössel O, Schlegel WC (eds) IFMBE Proc of World Congress on Medical Physics and Biomedical Engineering, 7–12 September 2009, Munich, Germany. Vol. 25/3. Springer
• 2. Berger MJ, Hubbell JH, Seltzer SM et al. (2010) XCOM: Photon cross-section database (v. 1.5). NIST, Gaithersburg, MD. http://physics.nist.gov/xcom
• 3. Fong PM, Keil DC, Does MD, Gore JC (2001) Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere. Phys Med Biol 46:3105–3113
• 4. Herold DM, Das IJ, Stobbe CC, Iyer RV, Chapman JD (2000) Gold microspheres: a selective technique for producing biologically effective dose enhancement. Int J Radiat Biol 76;10:1357–1364
• 5. Jones BL, Krishnan S, Cho SH (2010) Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations. Med Phys 37;7:3809–3816
• 6. Knight KR, McCann JJ, Vanderkolk CA, Coe SA, O’Brien BM (1990) The redistribution of collagen in expanded pig skin. Braz J Plast Surg 43:565–570
• 7. McMahon SJ, Hyland WB, Muir MF et al. (2011) Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles. Scientific Reports 1:18 (9 pp) (doi: 10.1038/srep00018)
• 8. McMahon SJ, Mendenhall MH, Jain S, Currell F (2008) Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles. Phys Med Biol 53:5635–5651
• 9. Nguyen Q, Fanous MA, Kamm LH, Khalili AD, Schuepp PH, Zarkadas CG (1986) Comparison of the amino acid composition of two commercial porcine skins (rind). J Agric Food Chem 34:565–572
• 10. Norman A, Adams FH, Riley RF (1978) Cytogenetic effects of contrast media and triiodobenzoic acid derivatives in human lymphocytes. Radiology 129:199–203
• 11. Poludniowski G, Landry G, Deblois F, Evans PM, Verhaegen F (2009) SpekCalc: a program to calculate photon spectra from tungsten anode X-ray tubes. Phys Med Biol 54;19:433–438
• 12.Regulla D, Friedland W, Hieber L, Panzer W, Seidenbusch M, Schmid E (2000) Spatially limited effects of dose and LET enhancement near tissue/gold interfaces at diagnostic X-ray qualities. Radiat Prot Dosim 90;1/2:159–163