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Computer simulation of temperature distribution on a solid target for 201Tl production

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Thallium-201 is of great interest in nuclear medicine for diagnostic purposes. It is produced by the 203Tl(p,3n)201Pb nuclear reaction. Since the target for 201Tl production is a solid target and the maximum beam current for the irradiation has a direct relation with its temperature surface, therefore, the control of temperature during the irradiation is essential. Designing a proper cooling system is one of the important and determining parameters in radionuclide production efficiency. Non-controlled temperature would cause melting and consequently loss of target materials that could be very costly especially when an isotopically enriched material is used. In this study, the heat transfer and temperature distribution on the target has been simulated based on a computational fluid dynamics (CDF) code for the thermal behavior of the target during the irradiation and under the different beam currents, cooling flow rates and target designing. The results on the routinely used target for the production of 201Tl in AMIRS, showed that there was a good linearity between proton beam currents (in the range of 100–350 mi A) and maximum temperature on the thallium target (345–458 K). The results also showed that the flow rate of the cooling water can be brought down (from routinely used 45 L/min) to 15 L/min without any risk of melting of target material.
Czasopismo
Rocznik
Strony
283--289
Opis fizyczny
Bibliogr. 14 poz., rys.
Twórcy
autor
autor
autor
  • Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P. O. Box 31485-498, Karaj, Iran, Tel.: +98 261 441 1101, Fax: +98 261 441 1106, mraboudzadeh@nrcam.org
Bibliografia
  • 1. Arpaci VS (1966) Conduction heat transfer. Addison-Wesley Publication Co., Reading Mass, pp 32–60
  • 2. Dadparvar S, Hussain R, Esteves F et al. (2002) Thallium-201 imaging in evaluation of Hodgkin’s disease. Cancer J 8;6:469–475
  • 3. Frater CJ, Murray IP, Rossleigh M (2001) Tl-201 scintigraphy in muscle trauma. Clin Nucl Med 26;1:72–73
  • 4. Haas RLM, Valdés-Olmos RA, Hoefnagel CA et al. (2003) Thallium-201-chloride scintigraphy in staging and monitoring radiotheraphy response in follicular lymphoma patients. Radiother Oncol 69;3:323–328
  • 5. Hardoff R, Baron E, Sheinfeld M (1991) Early and late lesion-to-non lesion ratio of Tl-201-chloride uptake in the evaluation of cold thyroid nodules. J Nucl Med 32;10:1873–1876
  • 6. Human GP, Dormehl I (1991) Imaging of the myocardium with thallium-201. S Afr Med J 59;15:524–528
  • 7. IAEA (2005) Standardized high current solid targets for cyclotron production of diagnostic and therapeutic radionuclides. STI/DOC/010/432. TECDOC-1412. International Atomic Energy Agency, Vienna
  • 8. Lauer MS (2005) Prediction of the death or myocardial infarction by exercise single proton emission computed tomography perfusion scintography in patients who have recent coronary artery stenting. Am Heart J 149;3:534–540
  • 9. Lide DR (ed) (2004) Handbook of chemistry and physics, 84th ed. CRC Press, Boca Raton
  • 10. Lin CC, Ding HJ, Chen YW, Huang WT, Kao A (2004) Usefulness of thallium-201 muscle perfusion scan to investigate perfusion reserve in the lower limbs of type 2 diabetic patients. J Diabetes Complications 18;4:233–236
  • 11. Perry RH, Green DW (eds) (1997) Perry’s chemical engineers’ handbook, 7th ed. McGraw-Hill, New York
  • 12. Sehweil AM, McKillop JH, Milroy R, Wilson R, Abdel-Dayem HM, Omar YT (1989) Mechanism of 201Tl uptake in tumors. Eur J Nucl Med 15;7:376–379
  • 13. Sudo Y, Miyata K, Ikawa H, Kaminga M, Ohkawara M (1985) Experimental study of differences in DNB heat flux between upflow and downflow in vertical rectangular channel. J Nucl Sci Technol 22:604–618
  • 14. Ziegler JF, Biersack JP, Littmark U (1985) The stopping and range of ions in solids. Pergamon Press, New York
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ8-0007-0016
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