Production of 18F by proton irradiation of C6H6NF and C6H5NF2

• Autorzy: Běták E. , Mikołajczak R. , Staniszewska J. , Mikołajewski S. , Rurarz E. , Wojtkowska J.
• Języki publikacji: EN

Abstrakty

EN

Fluorin--18 can be produced directly by the (p,pn) reaction and also indirectly by the (p,2n) reaction on the 19F target. The overall cross section for both routes is 108 plus or minus 20 mb at 22.5 plus or minus 2.5 MeV. In this work, we obtained 18F, using 25 MeV protons on 2\--fluoroaniline and 2,4-difluoroaniline targets. The chemical separation yield was 46 š 7% and 47 plus or minus 12% for 2-fluoroaniline and 2,4-difluoroaniline, respectively. Low-current 1 h irradiations led to 90 mi Ci of 18F produced from 2-fluoroaniline bombarded with a 70 nA beam (in good agreement with the theoretical value, 96 mi Ci) and to 76 mi Ci of 18F in case of 2,4-difluoroaniline and a 33 nA beam (prediction 85 mi Ci). Both values are close to the thick target result reported by Dmitriev and Molin [4] for 22 MeV protons.

Słowa kluczowe

EN

radiopharmaceuticals; positron emitters; radiochemistry; 18F; cyclotron; production cross section

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2011
• Tom: Vol. 56, No. 4
• Strony: 269--276
• Opis fizyczny: Bibliogr. 32 poz., rys.

Twórcy

autor

Běták E.

autor

Mikołajczak R.

autor

Staniszewska J.

autor

Mikołajewski S.

autor

Rurarz E.

autor

Wojtkowska J.

• Institute of Physics, Slovak Academy of Sciences, 84511 Bratislava, Slovakia and Faculty of Philosophy and Science, Silesian University, 74601 Opava, Czech Republic, Tel.: [phone], Fax: [phone],

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