Routine simultaneous production of no-carrier-added high purity 64Cu and 67Ga

• Autorzy: Al Rayyes A. H. , Ailouti Y.
• Języki publikacji: EN

Abstrakty

EN

A routine production method of no-carrier-added 64Cu was performed. A copper target support is electroplated by gold then an optimized thickness of enriched 68Zn layer is deposited. The 68Zn target was bombarded with a 23.5 MeV and 250 miA proton beam, generating the main nuclear reactions 68Zn(p,2n)67Ga and 68Zn(p,alfa n)64Cu. A semi-automated separation method using a chromatographic column system was developed for 64CuCl2 production. A 600 mCi batch of 64Cu is produced at the end of separation and purification chemistry. The radionuclidic purity of 64Cu was less than 98% as required by the United States and European Pharmacopoeias. Radiochemical purity and activity concentration is suitable for labeling different ligands to produce diagnostic and therapeutic radiopharmaceuticals.

Słowa kluczowe

EN

64Cu; targetry; radioisotope production; ion-exchange chromatography

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2011
• Tom: Vol. 56, No. 4
• Strony: 259--262
• Opis fizyczny: Bibliogr. 13 poz., rys.

Twórcy

autor

Al Rayyes A. H.

autor

Ailouti Y.

• Cyclotron Division, Chemistry Department, Atomic Energy Commission of Syria, P. O. Box 6091, Damascus, Syria, Tel.: [phone], Fax: [phone],

Bibliografia

• 1. Adam-Rebeles R, Van den Winkel P, De Vis L (2007) Optimization of production yields, radionuclidic purity and hot cell shielding of SPECT and PET radionuclides produced by proton irradiation in variable energy 30 MeV cyclotrons – Part 67Ga. Appl Radiat Isot 65:995–1013
• 2. Avila-Rodriguez MA, Nyeb JA, Nickles RJ (2007) Simultaneous production of high specific activity 64Cu and 61Co with 11.4 MeV protons on enriched 64Ni nuclei. Appl Radiat Isot 65:1115–1120
• 3. Blower PJ, Lewis JS, Zweit J (1996) Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nucl Med Biol 23;8:957–980
• 4. Hou X, Jacobsen U, Jorgensen JC (2002) Separation of no-carrier-added 64Cu from a proton irradiated 64Ni enriched nickel target. Appl Radiat Isot 57:773–777
• 5. IAEA (2001) Charged particle cross-section database for medical radioisotope production. Diagnostic radioisotopes and monitor reactions. Final report of a co-ordinated research project. IAEA-TECDOC-1211. International Atomic Energy Agency, Vienna
• 6. Le Van So, Pellegrini P, Katsifis A, Howse J, Greguric I (2008) Radiochemical separation and quality assessment for the 68Zn target based 64Cu radioisotope production. J Radioanal Nucl Chem 277;2:451–466
• 7. McQuade P, Martin KE, Castle TC et al. (2005) Investigation into 64Cu-labeled bis(selenosemicarbazone) and bis(thiosemicarbazone) complexes as hypoxia imaging agents. Nucl Med Biol 32:147–156
• 8. Obata A, Kasamatsu S, Lewis JS et al. (2005) Basic characterization of 64Cu-ATSM as a radiotherapy agent. Nucl Med Biol 32:21–28
• 9. Obata A, Kasamatsu S, McCarthy DW et al. (2003) Production of therapeutic quantities of 64Cu using a 12 MeV cyclotron. Nucl Med Biol 30:535–539
• 10. Obata A, Yoshimoto M, Kasamatsu S et al. (2003) Intratumoral distribution of 64Cu-ATSM: a comparison study with FDG. Nucl Med Biol 30:529–534
• 11. Szelecsenyi F, Steyn GF, Kovacs Z et al. (2005) Investigation of the 66Zn(p,2pn)64Cu and 68Zn(p,x)64Cu nuclear processes up to 100 MeV: production of 64Cu. Nucl Instrum Methods Phys Res B 240:625–637
• 12. Wadas TJ, Wong EH, Weisman GR, Anderson CJ (2007) Copper chelation chemistry and its role in copper radiopharmaceuticals. Curr Pharm Des 13:3–16
• 13. Ziegler JF, Biersack JP, Ziegler MD (2010) Stopping and range of ions in matter (SRIM) programme. http://www.srim.org