Identyfikatory
Warianty tytułu
Języki publikacji
Abstrakty
A routine production method of no-carrier-added 64Cu was performed. A copper target support is electroplated by gold then an optimized thickness of enriched 68Zn layer is deposited. The 68Zn target was bombarded with a 23.5 MeV and 250 miA proton beam, generating the main nuclear reactions 68Zn(p,2n)67Ga and 68Zn(p,alfa n)64Cu. A semi-automated separation method using a chromatographic column system was developed for 64CuCl2 production. A 600 mCi batch of 64Cu is produced at the end of separation and purification chemistry. The radionuclidic purity of 64Cu was less than 98% as required by the United States and European Pharmacopoeias. Radiochemical purity and activity concentration is suitable for labeling different ligands to produce diagnostic and therapeutic radiopharmaceuticals.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
259--262
Opis fizyczny
Bibliogr. 13 poz., rys.
Twórcy
autor
autor
- Cyclotron Division, Chemistry Department, Atomic Energy Commission of Syria, P. O. Box 6091, Damascus, Syria, Tel.: +963 11 213 2580, Fax: +963 11 611 2289, cscientific@aec.org.sy
Bibliografia
- 1. Adam-Rebeles R, Van den Winkel P, De Vis L (2007) Optimization of production yields, radionuclidic purity and hot cell shielding of SPECT and PET radionuclides produced by proton irradiation in variable energy 30 MeV cyclotrons – Part 67Ga. Appl Radiat Isot 65:995–1013
- 2. Avila-Rodriguez MA, Nyeb JA, Nickles RJ (2007) Simultaneous production of high specific activity 64Cu and 61Co with 11.4 MeV protons on enriched 64Ni nuclei. Appl Radiat Isot 65:1115–1120
- 3. Blower PJ, Lewis JS, Zweit J (1996) Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nucl Med Biol 23;8:957–980
- 4. Hou X, Jacobsen U, Jorgensen JC (2002) Separation of no-carrier-added 64Cu from a proton irradiated 64Ni enriched nickel target. Appl Radiat Isot 57:773–777
- 5. IAEA (2001) Charged particle cross-section database for medical radioisotope production. Diagnostic radioisotopes and monitor reactions. Final report of a co-ordinated research project. IAEA-TECDOC-1211. International Atomic Energy Agency, Vienna
- 6. Le Van So, Pellegrini P, Katsifis A, Howse J, Greguric I (2008) Radiochemical separation and quality assessment for the 68Zn target based 64Cu radioisotope production. J Radioanal Nucl Chem 277;2:451–466
- 7. McQuade P, Martin KE, Castle TC et al. (2005) Investigation into 64Cu-labeled bis(selenosemicarbazone) and bis(thiosemicarbazone) complexes as hypoxia imaging agents. Nucl Med Biol 32:147–156
- 8. Obata A, Kasamatsu S, Lewis JS et al. (2005) Basic characterization of 64Cu-ATSM as a radiotherapy agent. Nucl Med Biol 32:21–28
- 9. Obata A, Kasamatsu S, McCarthy DW et al. (2003) Production of therapeutic quantities of 64Cu using a 12 MeV cyclotron. Nucl Med Biol 30:535–539
- 10. Obata A, Yoshimoto M, Kasamatsu S et al. (2003) Intratumoral distribution of 64Cu-ATSM: a comparison study with FDG. Nucl Med Biol 30:529–534
- 11. Szelecsenyi F, Steyn GF, Kovacs Z et al. (2005) Investigation of the 66Zn(p,2pn)64Cu and 68Zn(p,x)64Cu nuclear processes up to 100 MeV: production of 64Cu. Nucl Instrum Methods Phys Res B 240:625–637
- 12. Wadas TJ, Wong EH, Weisman GR, Anderson CJ (2007) Copper chelation chemistry and its role in copper radiopharmaceuticals. Curr Pharm Des 13:3–16
- 13. Ziegler JF, Biersack JP, Ziegler MD (2010) Stopping and range of ions in matter (SRIM) programme. http://www.srim.org
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ8-0007-0011