Preparation and evaluation of a [66Ga]gallium chitosan complex in fibrosarcoma bearing animal models

• Autorzy: Pourjavadi A. , Akhlaghi M. , Jalilian A. R.
• Języki publikacji: EN

Abstrakty

EN

[66Ga]gallium chitosan complex was prepared with a high radiochemical purity (greater than 99%) in dilute acetic acid solution. The radiochemical purity of [66Ga]gallium chitosan complex was checked by using paper chromatography technique. The prepared complex solution was injected intratumoral to fibrosarcoma-bearing mice and the leakage of radioactivity from injection site was investigated. Approximately, 85.4% of the injected dose was retained in the injection site 54 h after injection and most of the leaked radioactivity was accumulated in the blood, liver (0.5%) and lung (6.5%).

Słowa kluczowe

EN

chitosan; gallium-66; internal radiotherapy; fibrosarcoma; intratumoral injection

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2011
• Tom: Vol. 56, No. 1
• Strony: 35--40
• Opis fizyczny: Bibliogr. 36 poz., rys.

Twórcy

autor

Pourjavadi A.

autor

Akhlaghi M.

autor

Jalilian A. R.

• Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, P. O. Box 11365-9516, Tehran, Iran, Tel.: [phone], Fax: [phone],

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