Fungal Cells Permeabilization as a Convenient Tool of Bioreduction Enantioselectivity Control

• Autorzy: Brzezińska-Rodak M. , Żymańczyk-Duda E. , Klimek-Ochab M. , Lejczak B.
• Języki publikacji: EN

Abstrakty

EN

The application of nonionic detergents: Triton X100 and Tween 80, as permeabilizing agents was an effective tool allowing to control the asymmetric hydrogen transfer in the biocatalyzed, enantioselective reduction of acetophenone to the desired optical isomer of 1-phenylethanol. Depending on the permeabilization procedure, the application of Geotrichum candidum, after the Triton X100 was applied, resulted in the formation of the R-enantiomer (79 percent of chemical yield and 72 percent of e.e), whereas bioreduction following the use of Tween 80 led to the S-form of 1-phenylethanol (51 percent of yield and 93 percent of e.e).

Słowa kluczowe

EN

yeasts; bioreduction; acetophenone; permeabilization

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2009
• Tom: Vol. 83, nr 12
• Strony: 2113--2118
• Opis fizyczny: Bibliogr. 23 poz., rys.

Twórcy

autor

Brzezińska-Rodak M.

autor

Żymańczyk-Duda E.

autor

Klimek-Ochab M.

autor

Lejczak B.

• Department of Bioorganic Chemistry, Wrocław University of Technology, 50- 370 Wrocław, Wybrzeże Wyspiańskiego 27, Poland,

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