Synthesis, Characterization and Anti-inflammatory Activity of Some Organotin(IV) Complexes

• Autorzy: Rehman W. , Rehman S. , Muhammad B. , Shah S. T. , Tauseef I. , Guo C. -Y.
• Języki publikacji: EN

Abstrakty

EN

The synthesis and characterization of new coordination compounds of some organotin(IV) chlo rides with fexofenadine are reported; the ligand molecules appear to be bound to the tin atom through carbonyl oxygen atom. The structure of the synthesized compounds has been characterized by elemental analyses, and bonding in these complexes is discussed in terms of their IR, 1H NMR and through Mössbauer studies. The spectroscopic results obtained are in full agreement with the proposed 1:1 stoichiometry. The synthesized complexes have been screened for anti-inflammatory effect. The results obtained showed that triphenyltin(IV) derivatives of fexofenadine exhibited promising anti-inflammatory effect as compared to the other tin(IV) derivatives of the same ligand.

Słowa kluczowe

EN

fexofenadine; spectra; anti-inflammatory; organotin; coordination

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2009
• Tom: Vol. 83, nr 12
• Strony: 2043--2049
• Opis fizyczny: Bibliogr. 25 poz., rys.

Twórcy

autor

Rehman W.

autor

Rehman S.

autor

Muhammad B.

autor

Shah S. T.

autor

Tauseef I.

autor

Guo C. -Y.

• Department of Chemistry, Hazara University, Mansehra, Pakistan,

Bibliografia

• 1.            Budavari S. Eds., in: The Merck Index, 12th Edn., Merck and Co. Inc., Whitehouse, A. Markham and A.J. Wagstaff, Fexofenadine. Drugs, 1998, vol. 55, p. 269.
• 2.            Kerryn S. and Blair J., Drugs, 59, 301 (2000).
• 3.            Kehrer J.P., Crit. Rev. Toxicol, 231, 21 (1993).
• 4.            Davies A.G., Organotin Chemistry, 2nd ed., VCH Weinheim, Germany, (2004).
• 5.            Gielen M., J. Braz. Chem. Soc, 14, 870 (2003).
• 6.            Rehman W., Badshah A., Khan S. and Tyuet L.T.A., Eur. J. Med. Chem. (in press), DOI: 10.1016/j .ejmech.2009.04.027
• 7.            Shahid K, Shahzadi S. and Ali S., J. Serb. Chem. Soc, 74, 141 (2009).
• 8.            Bonire J.J. and Fricker S.P., J. Inorg. Biochem., 83, 217 (2001).
• 9.            Nath M., Pokharia S., Song X., Eng G., Gielen M., Kemmer M., Biesemans M., Willem R. and Vos D. De., Appl. Organomet. Chem., 17, 305 (2003).
• 10.          Ahmad M.S., Hussain M., Hanif M., Ali S. and Mirza B., Molecules, 12, 2348 (2007).
• 11.          Rehman W., Baloch M.K. and Badshah A., Eur. J. Med. Chem., 43, 2380 (2008).
• 12.          Rehman W., Baloch M.K., Badshah A. and Ali S., J. Chin. Chem. Soc, 52, 231 (2005).
• 13.          Rehman W., Baloch M.K., Badshah A. and Ali S., Spectrochim. Acta A, 65, 689 (2006).
• 14.          Rehman W., Baloch M.K. and Badshah A., J. Braz. Chem. Soc, 16, 827 (2005).
• 15.          Rehman W., Baloch M.K., Badshah A. and Ali S., Russ. J. Coord. Chem., 31, 856 (2005).
• 16.          Rehman W., Baloch M.K. and Badshah A., Russ. J. Inorg. Chem., 52, 102 (2007).
• 17.          Rehman W., Baloch M.K., Badshah A. and Muhammad B., Russ. J. Coord. Chem., 34, 256 (2008).
• 18.          Rehman W., Badshah A., Baloch M.K., Ali S., Hameed G. and Khan K.M., J. Chin. Chem. Soc, 51, 929 (2004).
• 19.          Sisido K., Takeda Y. and Kingawa Z., J. Am. Chem. Soc, 83, 538 (1961).
• 20.          Perrin D.D. and Armengo W.L.F., Purification of Laboratory Chemicals, Oxford: Pergamon (1988).
• 21.          Winter CA., Fisley E.A. and Nuss G.W., Proc. Soc. Exp. Biol. NY, 111, 544 (1962).
• 22.          Rehman W., Baloch M.K., Muhammad B., Badshah A. and Khan K.M., Chin. Sci. Bull, 49,119 (2004).
• 23.          Barbieri R., Huber F., Pellerito L., Ruisi G. and Silvestri A., 119nSn Mössbauer Studies on Tin Compounds, in: P.J. Smith (Ed.), Chemistry of Tin, Blackie Academic and Professional, London, 1998, p. 496.
• 24.          Lebl T., Holecek J. and Lycka A., Sci. Pap. Univ. Pardubice Ser., A2, 5 (1996).
• 25.          Basu Baul T.S.,Appl. Organometal Chem., 22, 195 (2008).