Novel Synthesis of 3-Methylisoxazolo[5,4-e][1,2,4]triazepin-4-ones

• Autorzy: Ryng S. , Zimecki M. , Mączyński M. , Głowiak T.
• Języki publikacji: EN

Abstrakty

EN

A convenient and general method for the preparation of new 7-substituted 3-methyl - isoxazolo[5,4-e][1,2,4]triazepin-4-ones from 5-amino-3-methylisoxazole-4-carboxylic acid methylhydrazide and carbonyl compounds is described. The synthesized compounds exhibited immunosuppressive properties in the murine humoral immune response in vivo and the proliferative response of mouse splenocytes to mitogens. The X-ray structure of a representative compound is reported.

Słowa kluczowe

EN

isoxazole; isoxazolo[5,4-e][1,2,4]triazepine; isoxazole-4-carboxylic acid methylhydrazide; immune suppression

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2009
• Tom: Vol. 83, nr 11
• Strony: 1967--1976
• Opis fizyczny: Bibliogr. 29 poz., rys.

Twórcy

autor

Ryng S.

autor

Zimecki M.

autor

Mączyński M.

autor

Głowiak T.

• Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9, 50-137 Wrocław, Poland,

Bibliografia

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