Syntheses and Characterization of the Pyrimido[1,2-][1,3,5]triazinthione as a New Ring System and Antibacterial Agent

• Autorzy: Waly M. A. , Abou Dobara M. I.
• Języki publikacji: EN

Abstrakty

EN

The pyrimido[4,5-e][1,2,4]triazine was prepared as a new ring system via annulation of the triazine ring onto the preformed pyrimidine derivative. Various S-benzoylisothiourea derivatives were synthesized by condensation of benzoylthiocyanate with amines. All the synthesized compounds were tested as antimicrobial agents and compounds 11 and 12 showed significant activity to ward to Klebsiella pneumoniae.

Słowa kluczowe

EN

organic syntheses; S-benzoylisothiourea; aminopyrimidine; antimicrobial; pyrimido[4,5-e][1,2,4]triazinthione

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2009
• Tom: Vol. 83, nr 9
• Strony: 1601--1607
• Opis fizyczny: Bibliogr. 8 poz., rys.

Twórcy

autor

Waly M. A.

autor

Abou Dobara M. I.

• Chemistry Department, Faculty of Science, Damiatta Branch, Mansoura University, Egypt,

Bibliografia

• 1.            Navashin S.M., Sazykin Yu.O.,Ivanitskaya I. P. et al. , in: Searchfor New Antitumor andAntiviral Drugs (in Russian), Zinatne, Riga, 140-163 (1978).
• 2.            Krylov Yu.R, Register of Drugs in Russia (RLS-1993), Infarmkhim, Moscow, 738 (1993).
• 3.            Kuechler C, Kuechler W. and Heinisch L., Arzneim.-Forsch., 16(8), 1122 (1966).
• 4.            Azev Yu.A., Postovskii I.Ya. and Pidemskii EX., Khim.-Farm. Zh., 14(4), 39 (1980).
• 5.            Azev Yu.A., Vereshchagina NN. and Postovskii I.Ya., Khim.-Farm. Zh., 15(11), 50(1981).
• 6. Orskov I. and Genus V., Klebsiella. In: Bergey's Manual of Systematic Bacteriology, Holt J.G., Krieg N.R., Sneath P.H.A., Staley J.T. and Williams S.T. (eds.), Williams and Wilkins, Baltimore, 461-165 (1986).
• 7.            Masic L.P. and Kikelij D., Tetrahedron, 57(33), 7073 (2001).
• 8.            Hideo A. and Jiro I., (Nissan Chemical Industries Co.) JP 25001816, B, date 19500621.