Enriched water-H2 18 O purification to be used in routine 18FDG production

• Autorzy: Al Rayyes A. H.
• Języki publikacji: EN

Abstrakty

EN

18O-water obtained from an 2-deoxy-2-[18F]-fluoro-D-glucose (18FDG, Synthera) synthesis unit is used for purification. The purification process consists of ultraviolet (UV) irradiation followed by a distillation in a preevacuated system. After purification, the loss of enriched water was about only 5 per cent. Organic compounds, radioisotopes, trace metals and gases are eliminated efficiently. Results show that there is no significant difference in the production yield of 2-deoxy-2-[18F]-fluoro-D-glucose ([18F]FDG) whether using purified enriched water by the proposed method of purification or using the new enriched water. This method offers the necessary precaution from contamination by tritium during the purification process. The obtained 18FDG or Na-18F using the purified 18O-water is of tritium free.

Słowa kluczowe

EN

H2 18 O; radiopharmaceuticals; purification; 18FDG

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2010
• Tom: Vol. 55, No. 3
• Strony: 401--405
• Opis fizyczny: BIbliogr. 8 poz., rys.

Twórcy

autor

Al Rayyes A. H.

• Cyclotron Division, Chemistry Department, Atomic Energy Commission of Syria, P. O. Box 6091, Damascus, Syria, Tel.: [phone], Fax: [phone],

Bibliografia

• 1. Asti M, Grassi, E, Sghedoni R et al. (2007) Purification by ozonolysis of 18O enriched water after cyclotron and the utilization of the purified water for the production of [18F]FDG (2-deoxy-2-[18F]-fluoro-D-glucose). Appl Radiat Isot 65:831–835
• 2. Gillies JM, Najim N, Zweit J (2006) Analysis of metal radioisotope impurities generated in [18O]H2O during water. the cyclotron production of fluorine-18. Appl Radiat Isot 64:431–434
• 3. Hamacher K, Coenen HH, Stocklin G (1986) Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27:235–238
• 4. Ito S, Sakane H, Deji S, Saze T, Nishizawa K (2006) Radioactive by-products in [18O]H2O used to produce 18F for [18F]FDG synthesis. Appl Radiat Isot 64:298–305
• 5. Ito S, Saze T, Sakane H, Ito S, Ito S, Nishizawa K (2004) Tritium in [18O] water containing [18F] fluoride for [18F] FDG synthesis. Appl Radiat Isot 61:1179–1183
• 6. Marengo M, Lodi F, Magi S, Cicoria G, Pancaldi D,Boschi S (2008) Assessment of radionuclidic impuritiesin 2-[18F]fluoro-2-deoxy-D-glucose([18F]FDG) routine production. Appl Radiat Isot 66:295–302
• 7. Moon WY, Oh SJ, Cheon JH et al. (2007) Simple purification of recovered [18O]H2O by UV, ozone and solid-phase extraction methods. Appl Radiat Isot 65:635–640
• 8. Wilson JS, Avila-Rodriguez MA, Johnson RR, Zyuzin A, McQuarrie SA (2008) Niobium sputtered Havar foils for the high-power production of reactive [18F] fluoride by proton irradiation of [18O]H2O targets. Appl Radiat Isot 66:565–570