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Target preparation of RbCl on a copper substrate by sedimentation method for the cyclotron production of no-carrier-added 85Sr for endotherapy

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EN
Abstrakty
EN
85Sr was produced via the 85Rb(p,n)85Sr reaction. Rubidium chloride deposition on copper substrate was carried out via the sedimentation method in order to produce strontium-85. Optimum conditions were achieved as a result of several repeated experiments with different amount of ethyl cellulose (EC) and acetone. 520 mg of RbCl, 208 mg of EC 4 mL of acetone were used to prepare a layer of enriched rubidium chloride of 11.69 cm2 area and 62.2 mg/cm2 thickness. Target quality control was done by a SEM photomicrograph and a thermal shock test. The deposited target was irradiated at a 20 ěA current and a 15 MeV proton beam for 30 min. No degradation was observed. The RbCl surface following bombardment was white, except the central area that was light brown and also without any crack or peeling off.
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Czasopismo
Rocznik
Strony
303--306
Opis fizyczny
Bibliogr. 17 poz., rys.
Twórcy
autor
autor
autor
  • Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, P. O. Box 31485-498, Karaj, Iran, Tel.: +98 261 443 6395, Fax: +98 261 446 4055, msadeghi@nrcam.org
Bibliografia
  • 1. Broeders CHM, Konobeyev AY, Korovin AY, Lunev VP, Blann M (2006) ALICE/ASH–Pre-compound and evaporation model code system for calculation of excitation functions, energy and angular distributions of emitted particles in nuclear reaction at intermediate energies, FZK 7183, http://bibliothek.fzk.de/zb/berichte/FZKA7183.pdf
  • 2. Giammarile F, Mogneti T, Blondet C, Desuziges C, Chauvot P (1999) Bone pain palliation with 85Sr therapy. Nucl Med 40:585–590
  • 3. Hamaoka T, Mardewell JE, Podoloffa DA, Hortobagyi GN, Ueno NT (2004) Bone imaging in metastatic breast cancer. J Clin Oncol 22:2942–2953
  • 4. Ido T, Hermanne A, Detroi F, Szucs Z, Mahunka L, Tárkányi F (2002) Re-measurement of the excitation functions of the 85Rb(p,4n)82Sr nuclear reaction near the threshold: relevance to the production of a 82Sr(82Rb) generator system with a medium energy cyclotron. Nucl Sci Technol 2:1310–1313
  • 5. Kandil SA, Scholten B, Hassan KF, Hanafi HA, Qaim SM (2009) A comparative study on the separation of radioyttrium from Sr and Rb target via ion-exchange and solvent extraction techniques, with special reference to the production of no-carrier-added 86Y, 87Y and 88Y using a cyclotron. J Radioanal Nucl Chem 279:823–832
  • 6. Kandil SA, Spahn I, Scholten B et al. (2007) Excitation functions of (α,xn) reactions on natRb and natSr from threshold up to 26 MeV: possibility of production of 87Y, 88Y and 89Zr. Appl Radiat Isot 65:561–568
  • 7. Kastleier S, Qaim SM, Nortier FM, Blessing G, Walt TN, Coenen HH (2002) Excitation function of 85Rb(p,xn)85,g,83,82,81Sr reactions up to 100 MeV: integral test of cross-section data, comparison of production routes of 83Sr and thick target yield of 82Sr. Appl Radiat Isot 56:685–695
  • 8. Koning AJ, Hilaire S, Duijvestijn MC (2004) TALYS: comprehensive nuclear reaction modeling. AIP Conf Proc 769:1154–1159
  • 9. Levkovskij VN (1991) Activation cross-section nuclides of average masses (a = 40–100) by protons and alpha-particles with average energies (E = 10–50 MeV). Intervesti, Moscow
  • 10. Nortier FM, Lenz JW, Smith PA (2007) Large-scale isotope production with an intense 100 MeV proton beam: recent target performance experience. In: Proc of the 18th Int Conf on Cyclotrons and their Applications, October 1–5, 2007, Giardini Naxos, Italy, pp 257–259
  • 11. Qaim SM, Steyn GF, Spahn I, Spellerberg S, Walt TN, Coenen HH (2007) Yield and purity of 82Sr produced via the natRb(p,xn)82Sr process. Appl Radiat Isot 65:247–252
  • 12. Ronai P, Winchell HS, Anger HO (1968) Skeletal survey for metastatic tumors of bone using 18F and 85Sr with scintillation camera and whole-body scanner. J Nucl Med 9:517–522
  • 13. Rösch F, Qaim SM (1993) Nuclear data relevant to the production of the positron-emitting technetium isotope 94mTc via the 94Mo(p,n)-reaction. Radiochim Acta 62:115–121
  • 14. Sadeghi M, Enferadi M, Nadi H (2010) Study of the cyclotron production of 172Lu: an excellent radiotracer. J Radioanal Nucl Chem, doi:10.1007/s10967-010-0649-7
  • 15. Sadeghi M, Kakavand T, Alipoor Z (2010) 85Sr production via proton induced on various targets using TALYS 1.0 code. Mod Phys Lett A 25;18:1541–1552
  • 16. Sadeghi M, Zali A, Sarabadani P, Majdabadi A (2009) Targetry of SrCO3 on a copper substrate by sedimentation method for the cyclotron production no-carrier-added 86Y. Appl Radiat Isot 67:2029–2032
  • 17.Ziegler JF, Biersack JP, Littmark U (2003) IBM-Research. New York
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ7-0014-0047
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