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Design and manufacture of krypton gas target for 81Rb production at a 30 MeV cyclotron

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The cyclotron of nuclear medicine research group at the Agricultural, Medical and Industrial Research School (AMIRS) has been producing several radionuclides such as 201Tl, 67Ga, 18F and 81Rb for nuclear medicine centers. Gas targets are utilized in a variety of cyclotron producing radionuclides which are used in nuclear medicine centers. We report a method for the design and manufacture of a cyclotron gas target which facilitates both the collection and processing of the krypton gas target as well as the desired 81Rb. In this study a gas target was designed for routine production of 81Rb (for a 81Rb/81mKr generator) through the nuclear reaction natKr(p,2n)81Rb → 81mKr. The incident energy of protons on the target was 26.5 MeV. The gas target was made of stainless steel. The length of the target was 251 mm with double titanium windows, 20 μm in thickness. A production yield of 3.18±0.27 mCi/μA·h was obtained which was more than 80% of the calculated yield (4.1 mCi/μA·h).
Słowa kluczowe
Czasopismo
Rocznik
Strony
225--231
Opis fizyczny
Bibliogr. 25 poz., rys.
Twórcy
autor
autor
autor
autor
  • Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P. O. Box 31485-498, Karaj, Iran, Tel.: +98 261 446 4062, Fax: +98 261 446 4053, Mraboudzadeh@nrcam.org
Bibliografia
  • 1. Acerbi E, Birattari C, Bonardi M, De Martinis C, Salomone A (1981) Kr(p,xn) excitation functions and 81Rb(81mKr) generator studies. Int J Appl Radiat Isot 32:465–475
  • 2. Blann N (1987) Calculation of excitation functions with code ALICE. In: Proc of the IAEA consultants’ meeting on data requests for medical radioisotope production, 20–24 April 1987, Tokyo, Japan. IAEA, Vienna, pp 20–24
  • 3. Buthelezi EZ, Nortier FM, Schroeder IW (2006) Excitation functions for the production of 82Sr by proton bombardment of natRb at energies up to 100 MeV. Appl Radiat Isot 64;8:915–924
  • 4. Firouzbakht ML, Schlyer DJ, Fowler JS (1999) Cryogenic target design considerations for the production of [18F] fluoride from enriched [18O]carbon dioxide. Nucl Med Biol 26:749–753
  • 5. Fremlin JH, Stammers K, Stewart FR (1978) A new generator for krypton-81m. Nucl Instrum Methods 156:369–373
  • 6. Gindler JE, Oselka MC, Friedman AM, Mayron LW, Kaplan E (1976) A gas target assembly for the production of high purity, high specific activity 81Rb. Int J Appl Radiat Isot 27:330–332
  • 7. Guillaume M, Brihaye C (1987) Generators of ultra short lived radionuclide for routine clinical applications. Radiochim Acta 41:119–130
  • 8. Hammond RG, Renton ML, Mackay DB, Waters SL (1997) Design and operation of a krypton-82 gas target for the regular high yield production of rubidium-81 for the preparation of krypton-81m generators. In: Proc of the 7th Int Workshop on Targetry and Target Chemistry, 8–11 June 1997, Heidelberg, Germany, pp 51–55
  • 9. Heselius SJ, Malmberg P, Solin O, Långström B (1987) Studies of proton beam penetration in nitrogen-gas target with respect to production and specific radioactivity of Carbon-11. Appl Radiat Isot 38:49–57
  • 10. Hess E, Blessing G, Coenen HH, Qaim SM (2000) Improved target system for production of high purity [18F]fluorine via the 18O(p,n)18F reaction. Appl Radiat Isot 52:1431–1440
  • 11. Homma Y, Kurata K (1979) Excitation functions for the production of 81Rb(81mKr) via the 79Br(α,2n)81Rb and the 81Br(3He,2n)81Rb reaction. Int J Appl Radiat Isot 30:345–348
  • 12. Hur MG, Kim SW, Yang SD et al. (2007) Design of a tandem target for a simultaneous production of C-11 and F-18 with 18 MeV. Nucl Instrum Methods B 261:800–802
  • 13. Jones T, Clark JC (1969) A cyclotron produced 81Rb-81mKr generator and its use in γ camera studies. Br J Radiol 42:237–238
  • 14. Kovacs Z, Tarkanyi F, Qaim SM, Stöcklin G (1991) Excitation functions for the formation of some radioisotopes of rubidium in proton induced nuclear reactions on Kr-nat, Kr-82 and Kr-83 with special reference to the production of Rb-81 (Kr-81m) generator radionuclide. Appl Radiat Isot 42:329–335
  • 15. Moroji T, Lambrecht RM, Wolf AP, Thakur ML (1980) Cyclotron isotopes and radiopharmaceuticals – XXX. Aspects of production, elution and automation of 81Rb/81mKr generators. Int J Appl Radiat Isot 31;1:51–59
  • 16. Mulders JJL (1984) Yield curves and beam current dependent production rates of Rb radioisotopes produced by protons on a krypton gas target. Int J Appl Radiat Isot 35:475–480
  • 17. Powell J, O’Neil JP (2006) Production of [15O]water at low-energy proton cyclotrons. Appl Radiat Isot 64:755–759
  • 18. Schnei RJ, Goldb CJ (1976) Production of rubidium-81 by the reaction 85Rb(p,5n)81Sr and decay of 81Sr. Int J Appl Radiat Isot 27:189–191
  • 19. Solin O, Heselius SJ, Lindblom P, Mangard PJ (1984) Production of 81Rb from Kr – a target study. J Labelled Compd Radiopharm 21:1275–1277
  • 20. Uhlir V, Gasper H, Helus F (1996) A new 81Rb-81mKr generator from enriched 82Kr gas for medical use. J Radioanal Nucl Chem 204:423–427
  • 21. Vandecasteele C, Goethals P, Sambre J, Slegers G (1981) Routine production of 81Rb-81mKr generators using the 81Kr(p,2n)81Rb reaction. Radiochem Radio 46;5:285–290
  • 22. Waters SL, Clark JC, Harlock PL, Brown C, Bett R, Sims HE (1986) Production of 81Rb using 60 MeV proton beam. Target development and aspect of recovery. J Labelled Compd Radiopharm 23:314–316
  • 23. Yang SD, Kim SW, Hur MG, Park JH, Chai JS, Yu KH (2007) Design and evaluation of tandem target for a simultaneous production of [11C]CH4 and [18F]-fluoride. Nucl Med Biol 34:117–120
  • 24. Yano Y, MacRae J, Anger HO (1970) Lung function studies using short-lived 81mKr and the scintillation camera. J Nucl Med 11:674–679
  • 25.Ziegler JF, Biersack JP, Littmark U (1985) The stopping and range of ions in solids. Pergamon Press, New York
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ7-0014-0037
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