Cyclotron production of technetium radionuclides using a natural metallic molybdenum thick target and consequent preparation of [Tc]-BRIDA as a radio-labelled kit sample

• Autorzy: Targholizadeh H. , Raisali G. , Jalilian A. R. , Rostampour N. , Ensaf M. , Dehghan M. K.
• Języki publikacji: EN

Abstrakty

EN

Numerous studies have focused on the use of accelerators for production of 99mTc, but all of these investigations have been performed at low-level currents. In this research, for the first time, we have constructed a high power level natural Mo target for production of 99mTc radioisotope using cyclotrons. A high purity natural molybdenum target (130 mg/cm2), suitable for proton beam power level of several kilowatts, has been constructed using a thermal spray coating method. The target was irradiated in a Cyclone30 accelerator using 160 mi A of 25 MeV proton beam energy for 1000 mi A-h. The activity of produced 99mTc was measured as 2.75 Ci. The technetium radionuclides produced were extracted using an MEK organic phase, followed by preparation of Tc-BRIDA as a radio-labelled kit sample. Animal biodistribution studies have been performed in rats. After administration of the radio-labelled Tc-BRIDA in rats, we observed most of the radioactivity accumulated in intestine as expected for IDA derivatives. The results of measurements show a successful production of Tc radionuclides (including 99mTc) in the bombarded target and subsequent labelling of the kit with Tc. It is anticipated that the developed coating method for the production of high power Mo targets using enriched 100Mo and a proton beam of about 1 mA is capable of producing about 100 Ci of 99mTc per irradiated target. The developed high power Mo target, if constructed using enriched 100Mo, could be a practical method for a large-scale production of 99mTc for local applications near cyclotron facilities.

Słowa kluczowe

EN

technetium; molybdenum target; thermal spray method; technetium radiochemical separation; radio--labelling

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2010
• Tom: Vol. 55, No. 1
• Strony: 113--118
• Opis fizyczny: Bibliogr. 15 poz., rys.

Twórcy

autor

Targholizadeh H.

autor

Raisali G.

autor

Jalilian A. R.

autor

Rostampour N.

autor

Ensaf M.

autor

Dehghan M. K.

• Physics Department, Imam Hossein University, Babaii highway, P. O. Box 16575-347, Tehran, Iran,

Bibliografia

• 1. Beaver JE, Hupf HB (1971) Production of 99mTc on a medical cyclotron. J Nucl Med 12;11:739–741
• 2. Bonardi M, Birattari C, Groppi F, Sabbioni E (2002) Thin-target excitation functions, cross-section and optimized thick-target yields for natMo(p,xn)94g,95m,95g,96(m+g)Tc nuclear reactions induced by protons from threshold up to 44 MeV, no-carrier-added radiochemical separation and quality control. Appl Radiat Isot 57:617–635
• 3. Brookhaven National Laboratory (1998) Nuchart, version 4.0.0. National Nuclear Data Center, BNL
• 4. Challana MB, Comsana MNH, Abou-Zeidb MA (2007) Thin target yields and MPIRE-II predictions on the accelerator production of technetium-99m. J Nucl Radiat Phys 2;1:1–12
• 5. Eckelman WC (2009) Unparalleled contribution of technetium-99m to medicine over 5 decades. J Am Coll Cardiol Img 2:364–368
• 6. IAEA (1995) Alternative technologies for 99mTc generators. IAEA-TECDOC-852. International Atomic Energy Agency, Vienna
• 7. IAEA (1999) Production technologies for molybdenum- 99 and technetium-99m. IAEA-TECDOC-1065. International Atomic Energy Agency, Vienna
• 8. Khandaker MU, Uddin MS, Kim KS, Lee YS, Kim GN (2007) Measurement of cross-sections for the (p,xn) reactions in natural molybdenum. Nucl Instrum Methods Phys Res B 262:171–181
• 9. Lagunas-Solar MC, Kiefer PM, Carvacho OF, Lagunas CA, Ya Po Cha (1991) Cyclotron production of NCA 99mTc and 99Mo, an alternative non-reactor supply source of instant 99mTc and 99Mo → 99mTc generators. Appl Radiat Isot 42;7:643–657
• 10. Pawlowski L (1995) Engineering of thermal spray coatings. John Wiley & Sons, Inc., New York
• 11. Rosch F, Qaim SM (1993) Nuclear data relevant to the production of the positron emitting technetium isotope Tc-94m via the Mo-94(p,n) reaction. Radiochim Acta 62:115–121
• 12. Takacs S, Szucs Z, Tarkanyi F, Hermanne A, Sonck M (2003) Evaluation of proton induced reactions on 100Mo new cross-sections for production of 99mTc and 99Mo. J Radioanal Nucl Chem 257;1:195–201
• 13. Takacs S, Tarkanyi F, Sonck M, Hermanne A (2002) Investigation of the natMo(p,xn)96mgTc nuclear reaction to monitor proton beam: new measurements and consequences on the earlier reported data. Nucl Instrum Methods Phys Res B 198:183–196
• 14. Uddin MS, Hagiwara M, Tarkanyi F, Ditroi F, Baba M (2004) Experimental studies on the proton-induced activation reactions of molybdenum in the energy range 22–67 MeV. Appl Radiat Isot 60:911–920
• 15.Ziegler JF, Biersack JP (2003) SRIM 2003.20, http://www.SRIM.org