Studies of recombination chambers filled with nitrogen for BNCT dosimetry

• Autorzy: Tulik P. , Golnik N.
• Języki publikacji: EN

Abstrakty

EN

Dosimetric characterization of therapy beams for boron neutron capture therapy (BNCT) involves determination of dose components and among them the “nitrogen” dose due to protons generated by neutron capture on 14N. In this work, investigations were carried out using a graphite recombination chamber in order to determine the 14N capture, gamma, and fast neutron dose components. The separation of the dose components is based on differences in the shape of the saturation curve, depending on the LET spectrum of the investigated radiation. The measurements were performed in reference radiation fields at the Institute of Atomic Energy at Świerk and at a reactor beam of the INP Řež (the Czech Republic). The gamma component was determined with an accuracy of about 5%, while the variations in its value could be monitored with an accuracy of about 0.5%. Relative changes in the beam components (thermal/fast neutrons) could be detected on line with an accuracy of about 5%. It was shown that the chamber with tissue-equivalent cups could be used for the determination of the 14N capture dose at different depths in tissue.

Słowa kluczowe

EN

recombination chamber; BNCT; dose components

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2009
• Tom: Vol. 54, No. 4
• Strony: 255--259
• Opis fizyczny: Bibliogr. 12 poz., rys.

Twórcy

autor

Tulik P.

autor

Golnik N.

• Institute of Atomic Energy, 05-400 Otwock-Świerk, Poland, Tel.: [phone], Fax: [phone],

Bibliografia

• 1. Ariyoshi Y, Shimahara M, Kimura Y et al. (2006) Boron neutron capture therapy for advanced and/or recurrent oral cavity. In: Nakagawa Y, Kobayashi T, Fukusa H (eds) Proc of the 12th Int Congress on Neutron Capture Therapy, 9–13 October 2006, Kagawa, Japan, pp 10–13
• 2. Diaz AZ (2003) Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician’s point of view. J Neuro-Oncol 62:101–109
• 3. Golnik N (1995) Microdosimetry using a recombination chamber: method and applications. Radiat Prot Dosim 61:125–128
• 4. Golnik N (1996) Recombination methods in the dosimetry of mixed radiation. Report IAE-20/A. Institute of Atomic Energy, Otwock-Świerk, Poland
• 5. Golnik N, Józefowicz K, Králik M (2002) Measurements of H*(10) in reference neutron fields using Bonner sphere spectrometry and LET spectrometry. Nucl Instrum Methods Phys A 476:365–368
• 6. Králík M, Novotný M (1995) Response functions of Bonner spheres with small cylindrical 3He proportional counter determined by Monte Carlo calculations. Report CMI-GR2070/95. The Czech Metrology Institute, Czech Republic
• 7. Králík M, Novotný M (1997) Calibration of the CMI Bonner sphere spectrometer. Report CMI-911-01/97. The Czech Metrology Institute, Czech Republic
• 8. Marek M, Burian J, Pospisil S (2001) Boron neutron capture therapy. In: Proc of the 3rd Int Workshop on Radiation Imaging Detectors, 23–27 September 2001, Sardinia, Italy
• 9. Miyatake SI, Tamura Y, Kawabata S et al. (2006) Clinical results of BNCT for malignant maningiomas. In: Nakagawa Y, Kobayashi T, Fukusa H (eds) Proc of the 12th Int Congress on Neutron Capture Therapy, 9–13 October 2006, Kagawa, Japan, pp 51–53
• 10. Roth BM, Bonomi MR, González SJ et al. (2006) BNCT clinical trials of skin melanoma patients in Argentina. In:Nakagawa Y, Kobayashi T, Fukusa H (eds) Proc of the 12th Int Congress on Neutron Capture Therapy, 9–13 October 2006, Kagawa, Japan, pp 14–19
• 11. Zielczyński M, Golnik N (1994) Recombination index of radiation quality – measuring and applications. Radiat Prot Dosim 52:419–422
• 12. Zielczyński M, Golnik N (2000) Recombination chambers. Monografie IEA. Vol. 3. Institute of Atomic Energy, Otwock-Świerk (in Polish)